Autophagy as a targeted therapeutic approach for skin cancer: Evaluating natural and synthetic molecular interventions.

Autor:	Ali ML; Department of Pharmacy, University of Chittagong, Chattogram 4331, Bangladesh.; Pratyasha Health Biomedical Research Center, Dhaka 1230, Bangladesh., Roky AH; Pratyasha Health Biomedical Research Center, Dhaka 1230, Bangladesh.; Department of Pharmacy, International Islamic University Chittagong, Chattogram 4318, Bangladesh., Azad SMAK; Pratyasha Health Biomedical Research Center, Dhaka 1230, Bangladesh.; Department of Pharmacy, International Islamic University Chittagong, Chattogram 4318, Bangladesh., Shaikat AH; Pratyasha Health Biomedical Research Center, Dhaka 1230, Bangladesh.; Department of Pharmacy, International Islamic University Chittagong, Chattogram 4318, Bangladesh., Meem JN; Department of Pharmacy, University of Chittagong, Chattogram 4331, Bangladesh.; Pratyasha Health Biomedical Research Center, Dhaka 1230, Bangladesh., Hoque E; Pratyasha Health Biomedical Research Center, Dhaka 1230, Bangladesh.; Department of Pharmacy, International Islamic University Chittagong, Chattogram 4318, Bangladesh., Ahasan AMF; Pratyasha Health Biomedical Research Center, Dhaka 1230, Bangladesh.; Department of Pharmacy, International Islamic University Chittagong, Chattogram 4318, Bangladesh., Islam MM; Pratyasha Health Biomedical Research Center, Dhaka 1230, Bangladesh.; Department of Pharmacy, Daffodil International University, Dhaka 1216, Bangladesh., Arif MSR; Pratyasha Health Biomedical Research Center, Dhaka 1230, Bangladesh.; Department of Pharmacy, BGC Trust University Bangladesh, Chattogram 4381, Bangladesh., Mostaq MS; School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209-0497, USA., Mahmud MZ; Pioneer Dental College and Hospital, Dhaka 1229, Bangladesh., Amin MN; School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209-0497, USA., Mahmud MA; School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209-0497, USA.
Jazyk:	angličtina
Zdroj:	Cancer pathogenesis and therapy [Cancer Pathog Ther] 2024 Feb 01; Vol. 2 (4), pp. 231-245. Date of Electronic Publication: 2024 Feb 01 (Print Publication: 2024).
DOI:	10.1016/j.cpt.2024.01.002
Abstrakt:	Skin cancer, a prevalent malignancy worldwide, poses significant health concerns owing to its increasing incidence. Autophagy, a natural cellular process, is a pivotal event in skin cancer and has advantageous and detrimental effects. This duality has prompted extensive investigations into medical interventions targeting autophagy modulation for their substantial therapeutic potential. This systematic review aimed to investigate the relationship between skin cancer and autophagy and the contribution and mechanism of autophagy modulators in skin cancer. We outlined the effectiveness and safety of targeting autophagy as a promising therapeutic strategy for the treatment of skin cancer. This comprehensive review identified a diverse array of autophagy modulators with promising potential for the treatment of skin cancer. Each of these compounds demonstrates efficacy through distinct physiological mechanisms that have been elucidated in detail. Interestingly, findings from a literature search indicated that none of the natural, synthetic, or semisynthetic compounds exhibited notable adverse effects in either human or animal models. Consequently, this review offers novel mechanistic and therapeutic perspectives on the targeted modulation of autophagy in skin cancer. (© 2024 The Authors.)
Databáze:	MEDLINE
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