Genetic Predisposition for Gynecologic Cancers.
| Autor: | González Peña T; Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee., Huang M; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Comprehensive Cancer Center, University of Virginia Health, Charlottesville, Virginia. |
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| Jazyk: | angličtina |
| Zdroj: | Clinical obstetrics and gynecology [Clin Obstet Gynecol] 2024 Dec 01; Vol. 67 (4), pp. 660-665. Date of Electronic Publication: 2024 Oct 07. |
| DOI: | 10.1097/GRF.0000000000000894 |
| Abstrakt: | Hereditary cancer syndromes (HCS) are responsible for up to 10% of all cancers. At present, the majority of cancer susceptibility testing is initiated after a cancer diagnosis. There exists a significant opportunity for primary care providers including general obstetrician-gynecologists to engage in hereditary cancer risk assessment through adequate family history evaluation, initiation of genetic testing, and following the recommendations of national organizations. Identifying hereditary cancer genes may prompt primary prevention efforts such as enhanced screening, prevention, or personalized care strategies. We will review the literature regarding the approach and assessment of the most common gynecologic HCS. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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