Oxidative stress disrupts vascular microenvironmental homeostasis affecting the development of atherosclerosis.

Autor: Shao R; Medical School, Center for Translational Research in Clinical Medicine, Kunming University of Science and Technology, Kunming, China., Chen R; Yan'an Hospital Affiliated to Kunming Medical University, Kunming, China., Zheng Q; Medical School, Center for Translational Research in Clinical Medicine, Kunming University of Science and Technology, Kunming, China., Yao M; Medical School, Center for Translational Research in Clinical Medicine, Kunming University of Science and Technology, Kunming, China., Li K; Department of General Surgery II, The First People's Hospital of Yunnan Province, Kunming, China., Cao Y; Yunnan Key Laboratory of Innovative Application of Traditional Chinese Medicine, Department of Cardiovascular Surgery, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China., Jiang L; Medical School, Center for Translational Research in Clinical Medicine, Kunming University of Science and Technology, Kunming, China.; Yunnan Key Laboratory of Innovative Application of Traditional Chinese Medicine, Department of Cardiovascular Surgery, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
Jazyk: angličtina
Zdroj: Cell biology international [Cell Biol Int] 2024 Dec; Vol. 48 (12), pp. 1781-1801. Date of Electronic Publication: 2024 Oct 06.
DOI: 10.1002/cbin.12239
Abstrakt: Atherosclerosis is primarily an inflammatory reaction of the cardiovascular system caused by endothelial damage, leading to progressive thickening and hardening of the vessel walls, as well as extensive necrosis and fibrosis of the surrounding tissues, the most necessary pathological process causing cardiovascular disease. When the body responds to harmful internal and external stimuli, excess oxygen free radicals are produced causing oxidative stress to occur in cells and tissues. Simultaneously, the activation of inflammatory immunological processes is followed by an elevation in oxygen free radicals, which directly initiates the release of cytokines and chemokines, resulting in a detrimental cycle of vascular homeostasis abnormalities. Oxidative stress contributes to the harm inflicted upon vascular endothelial cells and the decrease in nitric oxide levels. Nitric oxide is crucial for maintaining vascular homeostasis and is implicated in the development of atherosclerosis. This study examines the influence of oxidative stress on the formation of atherosclerosis, which is facilitated by the vascular milieu. It also provides an overview of the pertinent targets and pharmaceutical approaches for treating this condition.
(© 2024 International Federation for Cell Biology.)
Databáze: MEDLINE
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