Salivary Antimicrobial Peptide in Patients With Dementia Before and After Clinical Oral Rehabilitation Programme: A Randomised Controlled Trial.

Autor: Chen MA; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Oral Hygiene, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan., Yang YH; Neuroscience Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.; Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan.; School of Post-Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Liu CK; Institute of Precision Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.; Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan., Matsuo K; Department of Oral Health Sciences for Community Welfare, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan., Hsu CC; Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, Taiwan.; National Center for Geriatrics and Welfare Research, National Health Research Institutes, Yunlin County, Taiwan., Lin YC; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Huang HL; Department of Oral Hygiene, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Jazyk: angličtina
Zdroj: Journal of oral rehabilitation [J Oral Rehabil] 2024 Oct 06. Date of Electronic Publication: 2024 Oct 06.
DOI: 10.1111/joor.13867
Abstrakt: Background: Emerging evidence suggests a link between salivary metabolite changes and neurodegenerative dementia, with antimicrobial peptides (AMPs) implicated in its pathogenesis.
Objective: We investigated the effects of a clinical oral rehabilitation programme tailored for dementia patients on salivary flow rate, AMP levels and oral health-related quality of life (OHRQoL).
Methods: Eligible patients were randomly assigned to either the experimental group (EG; n = 28) or the control group (CG; n = 27). Both groups received a leaflet on oral health. In addition, the EG received an oral care intervention that included individual lessons on oral muscle exercises and oral self-care practices. Saliva samples and OHRQoL data were collected at baseline and follow-up visits. Generalised estimating equation models were used to analyse the changes over time.
Results: At the 3-month follow-up, EG showed significantly lower histatin 5 (HTN-5) levels (β = -0.08; effect size [ES] = 0.72) than CG. At 6 months, EG exhibited improved salivary flow rate (β = 0.89; ES = 0.89) and OHRQoL (β = 6.99; ES = 1.31) compared to CG. Changes in salivary flow rate (β = 4.03), HTN-5 level (β = -0.78) and beta-defensin 2 level (BD-2) (β = -0.91) at 3 months predicted improved OHRQoL at 6 months (all p < 0.05).
Conclusions: Our clinical oral rehabilitation programme reduced the level of salivary HTN-5, increased salivary flow rate and enhanced OHRQoL in dementia patients. Furthermore, changes in salivary flow rate, HTN-5 level and BD-2 level were associated with improvements in patients' OHRQoL.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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