Dose-dependent effects of transcranial photobiomodulation on brain temperature in patients with major depressive disorder: a spectroscopy study.

Autor: Weerasekera A; Athinoula A. Martinos Center for Biomedical Imaging, 149 13th Street, Charlestown, Boston, MA, 2612, USA. aweerasekera@mgh.harvard.edu.; Department of Radiology, Massachusetts General Hospital (MGH), Boston, MA, USA. aweerasekera@mgh.harvard.edu., Coelho DRA; Division of Neuropsychiatry and Neuromodulation, Massachusetts General Hospital (MGH), Boston, MA, USA.; Department of Psychiatry, Harvard Medical School (HMS), Boston, MA, USA., Ratai EM; Athinoula A. Martinos Center for Biomedical Imaging, 149 13th Street, Charlestown, Boston, MA, 2612, USA.; Department of Radiology, Massachusetts General Hospital (MGH), Boston, MA, USA., Collins KA; Nathan Kline Institute (NKI), Orangeburg, NY, USA., Puerto AMH; Division of Neuropsychiatry and Neuromodulation, Massachusetts General Hospital (MGH), Boston, MA, USA.; Department of Psychiatry, Harvard Medical School (HMS), Boston, MA, USA., De Taboada L; NeuroThera, New York City, NY, USA., Gersten MB; Division of Neuropsychiatry and Neuromodulation, Massachusetts General Hospital (MGH), Boston, MA, USA., Clancy JA; Division of Neuropsychiatry and Neuromodulation, Massachusetts General Hospital (MGH), Boston, MA, USA., Hoptman MJ; Nathan Kline Institute (NKI), Orangeburg, NY, USA.; New York University (NYU) School of Medicine, New York City, NY, USA., Irvin MK; Nathan Kline Institute (NKI), Orangeburg, NY, USA., Sparpana AM; Nathan Kline Institute (NKI), Orangeburg, NY, USA., Sullivan EF; Nathan Kline Institute (NKI), Orangeburg, NY, USA., Song X; New York University (NYU) School of Medicine, New York City, NY, USA., Adib A; New York University (NYU) School of Medicine, New York City, NY, USA., Cassano P; Division of Neuropsychiatry and Neuromodulation, Massachusetts General Hospital (MGH), Boston, MA, USA.; Department of Psychiatry, Harvard Medical School (HMS), Boston, MA, USA., Iosifescu DV; New York University (NYU) School of Medicine, New York City, NY, USA.
Jazyk: angličtina
Zdroj: Lasers in medical science [Lasers Med Sci] 2024 Oct 07; Vol. 39 (1), pp. 249. Date of Electronic Publication: 2024 Oct 07.
DOI: 10.1007/s10103-024-04198-6
Abstrakt: This study aimed to evaluate the dose-dependent brain temperature effects of transcranial photobiomodulation (t-PBM). Thirty adult subjects with major depressive disorder were randomized to three t-PBM sessions with different doses (low: 50 mW/cm 2 , medium: 300 mW/cm 2 , high: 850 mW/cm 2 ) and a sham treatment. The low and medium doses were administered in continuous wave mode, while the high dose was administered in pulsed wave mode. A 3T MRI scanner was used to perform proton magnetic resonance spectroscopy ( 1 H-MRS). A voxel with a volume of 30 × 30 × 15 mm 3 was placed on the left prefrontal region. Brain temperature (°C) was derived by analyzing 1 H-MRS spectrum chemical shift differences between the water (~ 4.7 ppm) and N-acetyl aspartate (NAA) (~ 2.01 ppm) peaks. After quality control of the data, the following group numbers were available for both pre- and post-temperature estimations: sham (n = 10), low (n = 11), medium (n = 10), and high (n = 8). We did not detect significant temperature differences for any t-PBM-active or sham groups post-irradiation (p-value range = 0.105 and 0.781). We also tested for potential differences in the pre-post variability of brain temperature in each group. As for t-PBM active groups, the lowest fluctuation (variance) was observed for the medium dose (σ 2  = 0.29), followed by the low dose (σ 2  = 0.47), and the highest fluctuation was for the high dose (σ 2  = 0.67). t-PBM sham condition showed the overall lowest fluctuation (σ 2  = 0.11). Our 1 H-MRS thermometry results showed no significant brain temperature elevations during t-PBM administration.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.)
Databáze: MEDLINE
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