Glut-1-Negative Choroidal Malignant Melanoma with Liver Metastasis Recurrence 12 Years after Surgery without FDG Accumulation in a Recurrent Lesion on FDG-PET/CT: a Case Report.

Autor:	Shimamoto T; Department of Liver-Biliary-Pancreatic Disease, Matsuyama Red Cross Hospital, Japan., Ochi H; Department of Liver-Biliary-Pancreatic Disease, Matsuyama Red Cross Hospital, Japan., Fang C; Department of Liver-Biliary-Pancreatic Disease, Matsuyama Red Cross Hospital, Japan., Amano M; Department of Liver-Biliary-Pancreatic Disease, Matsuyama Red Cross Hospital, Japan., Tanaka T; Department of Liver-Biliary-Pancreatic Disease, Matsuyama Red Cross Hospital, Japan., Azemoto N; Department of Liver-Biliary-Pancreatic Disease, Matsuyama Red Cross Hospital, Japan., Mashiba T; Department of Liver-Biliary-Pancreatic Disease, Matsuyama Red Cross Hospital, Japan., Kimura K; Department of Surgery, Matsuyama Red Cross Hospital, Japan., Minagawa R; Department of Surgery, Matsuyama Red Cross Hospital, Japan., Ooshiro Y; Department of Pathology, Matsuyama Red Cross Hospital, Japan., Kodama T; Department of Ophthalmology, Matsuyama Red Cross Hospital, Japan., Yokota T; Department of Liver-Biliary-Pancreatic Disease, Matsuyama Red Cross Hospital, Japan.
Jazyk:	angličtina
Zdroj:	Internal medicine (Tokyo, Japan) [Intern Med] 2024 Oct 04. Date of Electronic Publication: 2024 Oct 04.
DOI:	10.2169/internalmedicine.4204-24
Abstrakt:	Choroidal malignant melanoma is a rare malignant tumor that develops in adult eyeballs. It causes early lymph node and distant metastasis. Fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (CT) is widely used for screening malignant melanoma metastases. We encountered a 58-year-old man with choroidal malignant melanoma in whom liver metastasis recurred 12 years after surgery, without any observable FDG accumulation. Immunostaining revealed the absence of glucose transporter type 1 (GLUT-1) expression, crucial for intracellular FDG uptake. The lack of FDG accumulation in the lesion could be attributed to the diminished cellular FDG uptake due to the absence of GLUT-1 expression.
Databáze:	MEDLINE
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