Quality of life in patients with myelin oligodendrocyte glycoprotein antibody associated disease compared to patients with AQP4-IgG positive neuromyelitis optica spectrum disorders: A Korean multicenter study.

Autor: Lyou HJ; Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea; Department of Neurology, Eunpyeong St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea., Shin HY; Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea., Lee HL; Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South Korea., Kwon YN; Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea., Oh SI; Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, South Korea., Oh J; Department of Neurology, Konkuk University Medical Center, Seoul, South Korea., Cho EB; Department of Neurology, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Jinju, South Korea., Kim S; Departments of Neurology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea., Baek SH; Department of Neurology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, South Korea., Kim BJ; Department of Neurology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, South Korea., Sohn E; Department of Neurology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, South Korea., Seok JM; Department of Neurology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, South Korea., Min JH; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea., Kim SW; Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea. Electronic address: kswneuro@yuhs.ac., Kim BJ; Department of Neurology, Neuroscience/Spine Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address: bjkim@skku.edu.
Jazyk: angličtina
Zdroj: Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2024 Nov; Vol. 91, pp. 105914. Date of Electronic Publication: 2024 Sep 30.
DOI: 10.1016/j.msard.2024.105914
Abstrakt: Background: Little is known about the quality of life (QOL) of patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). We compared QOL and associated factors in patients with MOGAD and aquaporin4 IgG (AQP4-IgG) positive neuromyelitis optica spectrum disorder (NMOSD).
Methods: This multicenter questionnaire study compared the QOL of 41 patients with MOGAD and 78 with AQP4-IgG positive NMOSD. Patients who were positive for AQP4-IgG or MOG antibodies were included. WHO Quality of Life Scale Brief Version was used to assess QOL in physical, psychological, social, and environmental domains. QOL, sleep quality, pain, fatigue, and depression were compared between the two groups. The factors associated with QOL in each group and the entire cohort were analyzed.
Results: The proportion of patients with poor QOL was not significantly different between MOGAD (51.22 %) and AQP4-IgG positive NMOSD (58.97 %, p = 0.054). In the MOGAD group, the pain score (β=-1.032, p = 0.001) and depression score (β=-0.694, p = 0.007) were negatively associated with physical and psychological QOL, respectively. Sleep quality was negatively associated with physical (β=-1.506, p = 0.034) and psychological (β =-2.064, p = 0.033) QOL. When the entire cohort was analyzed, a positive MOG antibody was independently associated with worse psychological QOL (β=-8.998, p = 0.013) compared to positive AQP4-Ab after adjustment for sleep quality, depression, fatigue, and pain.
Conclusions: The overall QOL of the patients of MOGAD was comparable to that of AQP4-IgG positive NMOSD. Patients with MOGAD were experiencing sleep disorder, fatigue, and depression at similar degrees to those of patients with AQP4-IgG positive NMOSD. Further consideration of sleep quality and psychological QOL is required to improve QOL in patients with MOGAD.
Competing Interests: Declaration of competing interest None of the authors has any potential conflicts of interest to disclose.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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