Aluminum phthalocyanine tetrasulfonate conjugated to surface-modified Iron oxide nanoparticles as a magnetic targeting platform for photodynamic therapy of Ehrlich tumor-bearing mice.

Autor: Fauiod OG; Pharmaceutical Nanotechnology Unit, Department of Medical Applications of Laser, National Institute of Laser Enhanced Sciences, Cairo University, Egypt., Fadel M; Pharmaceutical Nanotechnology Unit, Department of Medical Applications of Laser, National Institute of Laser Enhanced Sciences, Cairo University, Egypt., El-Hussein A; Laser Applications in Metrology, Photochemistry and Agriculture unit, National Institute of Laser Enhanced Sciences, Cairo University, Giza, Egypt; Faculty of Science, Galala University, Egypt., Fadeel DA; Pharmaceutical Nanotechnology Unit, Department of Medical Applications of Laser, National Institute of Laser Enhanced Sciences, Cairo University, Egypt. Electronic address: d_fadeel@cu.edu.eg.
Jazyk: angličtina
Zdroj: Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2024 Dec; Vol. 50, pp. 104356. Date of Electronic Publication: 2024 Oct 04.
DOI: 10.1016/j.pdpdt.2024.104356
Abstrakt: Background: Photodynamic therapy (PDT) is a targeted treatment option for cancers that are non-responding to ordinary anticancer therapies. It involves activating a photosensitizer with a light source of a specific wavelength to destroy targeted cells and their surrounding vasculature. Aluminum phthalocyanine tetra sulfonate (AlPcS 4 ) has gained attention as a second-generation photosensitizer for its strong absorption in the red-light region. AlPcS 4 can be conjugated to magnetic iron oxide nanoparticles (IONs) to provide targeted drug delivery to the tumor cells while reducing its undesired effect on healthy tissues in other body parts.
Methods: Magnetic glutamine functionalized iron oxide nanocomposites loaded with AlPcS 4 (IONs-NH 2 -AlPcS 4 ) were synthesized via the co-precipitation method. The conjugate (IONs-NH 2 -AlPcS 4 ) was characterized by TEM, Zeta potential, DLS, FTIR, and UV-VIS absorption spectroscopy. Furthermore, its photodynamic activity was investigated using albino mice with induced Ehrlich solid tumors.
Results: AlPcS 4 was successfully conjugated to IONs-NH 2 with a high loading efficiency of 54±2%. The synthesized conjugate exhibited a spherical shape, with 7 ± 2 nm particle size. The In vivo experiment revealed that the albino mice with induced Ehrlich solid tumor that were treated by combined PDT and magnetic targeting conjugate exhibited significant tumor regression and notably higher levels of necrotic tissue compared to the animals in other groups.
Conclusion: PDT mediated by magnetic targeting significantly inhibited tumor growth with minimal adverse effects, indicating its great potential as a promising strategy for solid cancer treatment.
Competing Interests: Declaration of competing interest The authors declare no competing interests.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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