Novel natural lipids based NLC containing finasteride improved androgenetic alopecia treatment in rats.

Autor: Siqueira Palmieri MG; Universidade Federal de Juiz de Fora, Department of Pharmaceutical Sciences, Juiz de Fora 36038330, Minas Gerais, Brazil; University of Pisa, Department of Pharmacy, Pisa 56122, Toscana, Italy., Pittella F; Universidade Federal de Juiz de Fora, Department of Pharmaceutical Sciences, Juiz de Fora 36038330, Minas Gerais, Brazil. Electronic address: frederico.pittella@ufjf.br., Tavares GD; Universidade Federal de Juiz de Fora, Department of Pharmaceutical Sciences, Juiz de Fora 36038330, Minas Gerais, Brazil., Silva AH; Universidade Federal de Santa Catarina, Department of Pharmaceutical Sciences, Florianópolis 88035972, Santa Catarina, Brazil., Creczynski Pasa TB; Universidade Federal de Santa Catarina, Department of Pharmaceutical Sciences, Florianópolis 88035972, Santa Catarina, Brazil., Vieira Aarestrup BJ; Universidade Federal de Juiz de Fora, Department of Morphology, Juiz de Fora 36038330, Minas Gerais, Brazil., Monti D; University of Pisa, Department of Pharmacy, Pisa 56122, Toscana, Italy., Paganini V; University of Pisa, Department of Pharmacy, Pisa 56122, Toscana, Italy., Tampucci S; University of Pisa, Department of Pharmacy, Pisa 56122, Toscana, Italy., Burgalassi S; University of Pisa, Department of Pharmacy, Pisa 56122, Toscana, Italy., do Amaral Corrêa JO; Universidade Federal de Juiz de Fora, Department of Pharmaceutical Sciences, Juiz de Fora 36038330, Minas Gerais, Brazil.
Jazyk: angličtina
Zdroj: International journal of pharmaceutics [Int J Pharm] 2024 Dec 05; Vol. 666, pp. 124804. Date of Electronic Publication: 2024 Oct 04.
DOI: 10.1016/j.ijpharm.2024.124804
Abstrakt: Androgenetic alopecia (AGA) is the most common hair loss disorder, affecting millions of men and women worldwide. Current formulations used to treat this condition often lead to a wide variety of side effects, ranging from allergies to sexual disfunction, especially when those drugs are administered orally. In this study, we developed and tested unique formulations containing nanostructured lipid carriers (NLC) composed of lipids extracted from fruit seeds, carrying finasteride to enhance efficacy of AGA treatment. By stabilizing the hydrophobic compounds in the solid matrix, three formulations of NLC were engineered and successfully prepared. Further an in vivo model of AGA was induced in rats by the administration of testosterone, as a platform to evaluate the efficiency of the formulations. The chosen formulation exhibited high bioavailability, medium size of 124.5 nm and PdI of 0.143, without systemic absorption. In addition, it promoted efficient and significant follicle restoration in AGA induced rats by increasing number of active bulbs and showed to be a safe formulation for topical application. The results of this research indicate that the presented formulation has significant potential to yield improved outcomes in AGA treatment.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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