Biocompatibility, antimicrobial efficacy, and therapeutic potential of cobalt carbonate nanoparticles in wound healing, sex hormones, and metabolic regulation in diabetic albino mice.

Autor: Umar A; Department of Zoology, Faculty of Life Sciences, Uniersity of Okara, Okara, 56130, Pakistan., Khan MS; Department of Zoology, Faculty of Life Sciences, Uniersity of Okara, Okara, 56130, Pakistan. Electronic address: samiikhan@uo.edu.pk., Wajid M; Department of Zoology, Faculty of Life Sciences, Uniersity of Okara, Okara, 56130, Pakistan., Ullah H; Institute of Chemistry, Uniersity of Okara, Okara, 56130, Pakistan.
Jazyk: angličtina
Zdroj: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Nov 19; Vol. 734, pp. 150773. Date of Electronic Publication: 2024 Oct 01.
DOI: 10.1016/j.bbrc.2024.150773
Abstrakt: Nanotechnology enables the manipulation of materials at the nanoscale, offering innovative solutions in various fields. Nanoparticles, with their small size and unique properties, have significant applications in the biomedical filed. The current study was designed to assess the biological applications of self-synthesized cobalt carbonate (CoCO 3 ) nanoparticles. The crystalline structure and chemical composition of the CoCO 3 -NPs were confirmed by SEM, XRD, and FTIR techniques. We observed the 16.58 nm size of novelly synthesized CoCO 3 NPS. The scanning electron microscope study confirmed a uniform cubic spinel structure. The biocompatibility and antimicrobial activity were checked in an invitro setup. We exposed albino mice to these synthesized NPs to study wound healing and metabolic effects. The results of biocompatibility analysis indicated hemolytic activity in a dose-dependent way, which showed no cytotoxic effect except at a higher concentration. Furthermore, the results showed enhanced wound healing processes in CoCO 3 -NP-treated albino mice as compared to the control group. CoCO 3 -NPs have considerable effect on the thyroid hormone and insulin levels in albino mice. The levels of T3, T4, and insulin were increased in a dose-dependent manner. Interactions between CoCO 3 -NPs and thyroxine and insulin were confirmed through molecular docking. We confirmed the antimicrobial efficiency of the nanoparticles using MIC values and zones of inhibition against Staphylococcus haemolyticus and Staphylococcus aureus. Despite their concentration-dependent biocompatibility concerns, the results are promising, as CoCO 3 -NPs hold potential for use in medical practice, particularly in advanced wound management and microbe inhibition.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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