The surfactant protein B polymorphisms (rs7316 and rs1130866) and their correlation with disease progression of COVID-19.

Autor: Behrouzi A; Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran., Sakhaee F; Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran., Ghazanfari Jajin M; Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran., Ahmadi I; Department of Physiology, School of Medicine, Ilam University of Medical Science, Ilam, Iran., Anvari E; Department of Physiology, School of Medicine, Ilam University of Medical Science, Ilam, Iran., Sotoodehnejadnematalahi F; Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran. Electronic address: fattah212@gmail.com., Fateh A; Department of Physiology, School of Medicine, Ilam University of Medical Science, Ilam, Iran; Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran. Electronic address: afateh2@gmail.com.
Jazyk: angličtina
Zdroj: Cytokine [Cytokine] 2024 Dec; Vol. 184, pp. 156775. Date of Electronic Publication: 2024 Oct 04.
DOI: 10.1016/j.cyto.2024.156775
Abstrakt: Background: It is critical to examine the pathogenic pathways in coronavirus disease 2019 (COVID-19) that resulted in the development of severe lung injury. Surfactant protein B (SFTPB) is a vital component for sustaining life and serves pivotal functions in the host's defensive mechanisms and alveolar surface tension reduction. Our study aimed to determine the effect of SFTPB rs7316 and rs1130866 variants on the course of disease in COVID-19 patients.
Methods: The study cohort comprised 3,184 individuals diagnosed with COVID-19. We employed the RFLP approach to determine the variations of the SFTPB genes.
Results: SFTPB rs7316 did not exhibit a statistically significant correlation with COVID-19 mortality across different inheritance models. But, after making more changes for SARS-CoV-2 variants, it was found that there was a strong link between the TT and TC genotypes of SFTPB rs7316 and death rates, especially for the Delta variant. Furthermore, our study's findings indicate a significant association between the SFTPB rs1130866 G allele and an elevated risk of mortality in COVID-19 across all variants of SARS-CoV-2.
Conclusions: The use of the SFTPB rs1130866 marker has the potential to facilitate the prediction of COVID-19 severity. On the other hand, for SFTPB rs7316, this kind of prediction seems to depend on the particular SARS-CoV-2 variants.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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