Red and Green LED Light Therapy: A Comparative Study in Androgenetic Alopecia.

Autor: Tantiyavarong J; Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand., Charoensuksira S; Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand., Meephansan J; Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand.; Samitivej Sukhumvit Hospital, Bangkok Dusit Medical Services PLC, Bangkok, Thailand., Hanvivattanakul S; Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand., Rayanasukha Y; National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand., Boonkoom T; National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand., Tantisantisom K; National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand.
Jazyk: angličtina
Zdroj: Photodermatology, photoimmunology & photomedicine [Photodermatol Photoimmunol Photomed] 2024 Nov; Vol. 40 (6), pp. e13004.
DOI: 10.1111/phpp.13004
Abstrakt: Background: Androgenetic alopecia (AGA) affects both men and women, characterized by progressive hair thinning. While current treatments like minoxidil and finasteride have efficacy limitations and side effects, low-level light therapy (LLLT) using red or near-infrared light has emerged as a promising alternative. Recent animal studies suggest potential benefits from green LED light, though human data are sparse.
Methods: This study utilized an innovative LED helmet emitting red and green LED light on respective halves of the frontal scalp, delivering an energy density of 40 J/cm 2 over 20 min. Clinical photography, physician evaluations on a 7-point scale, patient satisfaction, and measurements of hair density and hair diameter were employed. Data were analyzed using linear mixed-effects models, with significance set at p < 0.05.
Results: Seventeen participants (47.1% male, 52.9% female, average age 46.47 years) demonstrated notable improvements after 6 months of treatment. Red and green LEDs both significantly increased hair diameter, non-vellus hair density, and satisfaction scores. Notably, the red LED therapy resulted in a statistically significant decrease in vellus hair density and achieved a greater increase in hair diameter compared to the green LED therapy. Minimal adverse effects were reported, primarily consisting of tolerable scalp heat and mild redness.
Conclusion: Both red and green LED therapies effectively enhanced hair growth, increasing density and thickness over 6 months. Red LED demonstrated superior improvements in specific measures. Consequently, both therapies present safe and viable alternatives for the management of AGA, expanding the repertoire of available treatment options.
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: