Relapse Following Electroconvulsive Therapy for Schizophrenia: A Systematic Review and Meta-analysis.

Autor:	Aoki N; Department of Neuropsychiatry, Faculty of Medicine, Kansai Medical University, Osaka, 570-8506, Japan.; Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, NSW, 2031, Australia.; Black Dog Institute, Sydney, NSW, 2031, Australia., Tajika A; Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, 606-8501, Japan., Suwa T; Department of Neuropsychiatry, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan., Kawashima H; Department of Neuropsychiatry, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan., Yasuda K; Department of Neuropsychiatry, University of Yamanashi Faculty of Medicine, Yamanashi, 409-3898, Japan., Shimizu T; Department of Neuropsychiatry, Faculty of Medicine, Kansai Medical University, Osaka, 570-8506, Japan., Uchinuma N; Department of Neuropsychiatry, University of Yamanashi Faculty of Medicine, Yamanashi, 409-3898, Japan., Tominaga H; Department of Psychiatry, Mojimatsugae Hospital, Fukuoka, 800-0112, Japan., Tan XW; Department of Mood and Anxiety, Institute of Mental Health, 539747, Singapore., Koh AHK; Department of Mood and Anxiety, Institute of Mental Health, 539747, Singapore., Tor PC; Department of Mood and Anxiety, Institute of Mental Health, 539747, Singapore., Nikolin S; Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, NSW, 2031, Australia.; Black Dog Institute, Sydney, NSW, 2031, Australia., Martin D; Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, NSW, 2031, Australia.; Black Dog Institute, Sydney, NSW, 2031, Australia., Kato M; Department of Neuropsychiatry, Faculty of Medicine, Kansai Medical University, Osaka, 570-8506, Japan., Loo C; Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, NSW, 2031, Australia.; Black Dog Institute, Sydney, NSW, 2031, Australia., Kinoshita T; Department of Neuropsychiatry, Faculty of Medicine, Kansai Medical University, Osaka, 570-8506, Japan., Furukawa TA; Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, 606-8501, Japan., Takekita Y; Department of Neuropsychiatry, Faculty of Medicine, Kansai Medical University, Osaka, 570-8506, Japan.
Jazyk:	angličtina
Zdroj:	Schizophrenia bulletin [Schizophr Bull] 2024 Oct 04. Date of Electronic Publication: 2024 Oct 04.
DOI:	10.1093/schbul/sbae169
Abstrakt:	Background: Evidence regarding schizophrenia relapse following acute electroconvulsive therapy (ECT) is sparse compared with that for depression, and we have no clear consensus on relapse proportions. We aimed to provide longitudinal information on schizophrenia relapse following acute ECT. Study Design: This systematic review and meta-analysis included randomised controlled trials (RCTs) and observational studies on post-acute ECT relapse and rehospitalization for schizophrenia and related disorders. For the primary outcome, we calculated the post-acute ECT pooled relapse estimates at each timepoint (3, 6, 12, and 24 months post-acute ECT) using a random effects model. For subgroup analyses, we investigated post-acute ECT relapse proportions by the type of maintenance therapy. Study Results: Among a total of 6413 records, 29 studies (3876 patients) met our inclusion criteria. The risk of bias was consistently low for all included RCTs (4 studies), although it ranged from low to high for observational studies (25 studies). Pooled estimates of relapse proportions among patients with schizophrenia responding to acute ECT were 24% (95% CI: 15-35), 37% (27-47), 41% (34-49), and 55% (40-69) at 3, 6, 12, and 24 months, respectively. When continuation/maintenance ECT was added to antipsychotics post-acute ECT, the 6-month relapse proportion was 20% (11-32). Conclusion: Relapse occurred mostly within 6 months post-acute ECT for schizophrenia, particularly within the first 3 months. Relapse proportions plateaued after 6 months, although more than half of all patients could be expected to relapse within 2 years. Further high-quality research is needed to optimise post-acute ECT treatment strategies in patients with schizophrenia. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.)
Databáze:	MEDLINE
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