Application of nanoparticles as surface modifiers of dental implants for revascularization/regeneration of bone.

Autor: Soe ZC; Faculty of Dentistry, Graduate Program in Oral Biology, Chulalongkorn University, Bangkok, 10330, Thailand., Wahyudi R; Faculty of Dentistry, Graduate Program in Oral Biology, Chulalongkorn University, Bangkok, 10330, Thailand., Mattheos N; Department of Dental Medicine, Karolinska Institute, Stockholm, Sweden.; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand., Lertpimonchai A; Department of Periodontology, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand., Everts V; Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit, Amsterdam, The Netherlands.; Office of Research Affairs, Chulalongkorn University, Bangkok, 10330, Thailand., Tompkins KA; Office of Research Affairs, Chulalongkorn University, Bangkok, 10330, Thailand., Osathanon T; Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand.; Center of Excellence for Dental Stem Cell Biology, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand., Limjeerajarus CN; Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand. Chalida.N@chula.ac.th.; Center of Excellence in Genomics and Precision Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand. Chalida.N@chula.ac.th., Limjeerajarus N; Office of Research Affairs, Chulalongkorn University, Bangkok, 10330, Thailand.
Jazyk: angličtina
Zdroj: BMC oral health [BMC Oral Health] 2024 Oct 04; Vol. 24 (1), pp. 1175. Date of Electronic Publication: 2024 Oct 04.
DOI: 10.1186/s12903-024-04966-4
Abstrakt: Background: Osseointegrated dental implants are widely established as a first-choice treatment for the replacement of missing teeth. Clinical outcomes are however often compromised by short or longer-term biological complications and pathologies. Nanoparticle-coated materials represent a very active research area with the potential to enhance clinical outcomes and reduce complications of implant therapy. This scoping review aimed to summarize current research on various types of nanoparticles (NPs) used as surface modifiers of dental implants and their potential to promote biological and clinical outcomes.
Methods: A systematic electronic search was conducted in SCOPUS, PubMed and Google Scholar aiming to identify in vivo, in situ, or in vitro studies published between 2014 and 2024. Inclusion and exclusion criteria were determined and were described in the methods section.
Results: A total of 169 articles (44 original papers from Scopus and PubMed, and 125 articles from Google Scholar) were identified by the electronic search. Finally, 30 studies fit the inclusion criteria and were further used in this review. The findings from the selected papers suggest that nanoparticle-coated dental implants show promising results in enhancing bone regeneration and promoting angiogenesis around the implant site. These effects are due to the unique physicochemical properties of nanoparticle-coated implants and the controlled release of bioactive molecules from nanoparticle-modified surfaces.
Conclusion: Nanoscale modifications displayed unique properties which could significantly enhance the properties of dental implants and further accelerate revascularization, and osseointegration while facilitating early implant loading. Yet, since many of these findings were based on in-vitro/in-situ systems, further research is required before such technology reaches clinical application.
(© 2024. The Author(s).)
Databáze: MEDLINE
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