The supplementation of L-carnitine in critically ill patients with sepsis: a systematic review and meta-analysis of randomized controlled trials.

Autor: Meng C; Department of Emergency, Emergency General Hospital, XiBaHe South Road 29, Chaoyang District, Beijing, 100028, People's Republic of China., Ma Y; Department of General Surgery, The First Medical Center, Chinese PLA General Hospital, Fuxing Road 28, Haidian District, Beijing, 100039, People's Republic of China., Fu N; Department of Cardiology, Hebei Yanda Hospital, Langfang, 065201, People's Republic of China., Li J; Department of Emergency, Emergency General Hospital, XiBaHe South Road 29, Chaoyang District, Beijing, 100028, People's Republic of China., Sun B; Department of Emergency, Emergency General Hospital, XiBaHe South Road 29, Chaoyang District, Beijing, 100028, People's Republic of China., Li Z; Department of Emergency, Emergency General Hospital, XiBaHe South Road 29, Chaoyang District, Beijing, 100028, People's Republic of China., Wang Q; Department of Emergency, Emergency General Hospital, XiBaHe South Road 29, Chaoyang District, Beijing, 100028, People's Republic of China. qingw066@163.com., Liu P; Department of Cardiology, Ordos Central Hospital, Ordos School of Clinical Medicine, Inner Mongolia Medical University, 23 Yijin Huoluo West Street, Dongsheng District, Inner Mongolia, Ordos, 017000, People's Republic of China. wanguyisu@163.com.
Jazyk: angličtina
Zdroj: European journal of medical research [Eur J Med Res] 2024 Oct 05; Vol. 29 (1), pp. 488. Date of Electronic Publication: 2024 Oct 05.
DOI: 10.1186/s40001-024-02087-w
Abstrakt: Objectives: The evidence suggests that L-carnitine may reduce mortality in critically ill patients with sepsis. However, the conclusions of different studies are inconsistent. A meta-analysis was conducted to evaluate the effect of L-carnitine compliance on mortality in patients with sepsis.
Methods: A search of the PubMed, Embase, and Cochrane Library databases was conducted on 1 June 2024. The risk ratio (RR) was pooled with a 95% confidence interval (CI) for dichotomous data. The publications were subjected to a review in accordance with the guidelines set forth in the Cochrane Handbook and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). This study has been registered with INPLASY (number INPLASY202460086).
Results: A total of 356 patients were included in four randomized controlled trials. The results indicated that L-carnitine supplementation was not associated with 28-day mortality in sepsis patients (RR: 0.65; 95% CI 0.33-1.28; I 2  = 70%; P = 0.21). And there was no significant effect on 12-month mortality (RR: 0.72; 95% CI 0.47-1.11; I 2  = 0%; P = 0.14) compared to placebo.
Conclusions: The use of L-carnitine was not found to be significantly correlated with 28-day or 12-month mortality in patients with sepsis.
(© 2024. The Author(s).)
Databáze: MEDLINE
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