Effects of iron supplements and iron-containing micronutrient powders on the gut microbiome in Bangladeshi infants: a randomized controlled trial.

Autor: Baldi A; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. Baldi.a@wehi.edu.au.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia. Baldi.a@wehi.edu.au., Braat S; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Centre for Epidemiology and Biostatistics, University of Melbourne School of Population and Global Health, Carlton, Carlton, VIC, Australia.; Department of Infectious Diseases at the Peter Doherty Institute of Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia., Hasan MI; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.; International Center for Diarrheal Diseases Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Bennett C; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Barrios M; Advanced Technology and Biology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Jones N; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Abdul Azeez I; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Wilcox S; Advanced Technology and Biology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Roy PK; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Faculty of Science, University of Melbourne, Melbourne, VIC, Australia., Bhuiyan MSA; International Center for Diarrheal Diseases Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Ataide R; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Infectious Diseases at the Peter Doherty Institute of Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia., Clucas D; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.; Diagnostic Haematology, The Royal Melbourne Hospital, Parkville, VIC, Australia., Larson LM; Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA., Hamadani J; International Center for Diarrheal Diseases Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Zimmermann M; Medical Research Council Translational Immune Discovery Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, England, UK., Bowden R; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.; Advanced Technology and Biology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Jex A; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.; Faculty of Science, University of Melbourne, Melbourne, VIC, Australia., Biggs BA; Department of Infectious Diseases at the Peter Doherty Institute of Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.; Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, VIC, Australia., Pasricha SR; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. Pasricha.s@wehi.edu.au.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia. Pasricha.s@wehi.edu.au.; Diagnostic Haematology, The Royal Melbourne Hospital, Parkville, VIC, Australia. Pasricha.s@wehi.edu.au.; Clinical Haematology at The Royal Melbourne Hospital and the Peter MacCallum Cancer Centre, Parkville, VIC, Australia. Pasricha.s@wehi.edu.au.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Oct 05; Vol. 15 (1), pp. 8640. Date of Electronic Publication: 2024 Oct 05.
DOI: 10.1038/s41467-024-53013-x
Abstrakt: Anemia is highly prevalent globally, especially in young children in low-income countries, where it often overlaps with a high burden of diarrheal disease. Distribution of iron interventions (as supplements or iron-containing multiple micronutrient powders, MNPs) is a key anemia reduction strategy. Small studies in Africa indicate iron may reprofile the gut microbiome towards pathogenic species. We seek to evaluate the safety of iron and MNPs based on their effects on diversity, composition, and function of the gut microbiome in children in rural Bangladesh as part of a large placebo-controlled randomized controlled trial of iron or MNPs given for 3 months (ACTRN12617000660381). In 923 infants, we evaluate the microbiome before, immediately following, and nine months after interventions, using 16S rRNA gene sequencing and shotgun metagenomics in a subset. We identify no increase in diarrhea with either treatment. In our primary analysis, neither iron nor MNPs alter gut microbiome diversity or composition. However, when not adjusting for multiple comparisons, compared to placebo, children receiving iron and MNPs exhibit reductions in commensal species (e.g., Bifidobacterium, Lactobacillus) and increases in potential pathogens, including Clostridium. These increases are most evident in children with baseline iron repletion and are further supported by trend-based statistical analyses.
(© 2024. The Author(s).)
Databáze: MEDLINE
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