The role of JNK signaling pathway in organ fibrosis.

Autor:	Yao Z; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China., Lu Y; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China., Wang P; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China., Chen Z; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China., Zhou L; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China., Sang X; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China., Yang Q; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China., Wang K; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China. Electronic address: kuilongwang@zcmu.edu.cn., Hao M; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China; Songyang Research Institute of Zhejiang Chinese Medical University, Songyang, 323400, China. Electronic address: 20191032@zcmu.edu.cn., Cao G; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China. Electronic address: caog1984@zcmu.edu.cn.
Jazyk:	angličtina
Zdroj:	Journal of advanced research [J Adv Res] 2024 Oct 02. Date of Electronic Publication: 2024 Oct 02.
DOI:	10.1016/j.jare.2024.09.029
Abstrakt:	Background: Fibrosis is a tissue damage repair response caused by multiple pathogenic factors which could occur in almost every apparatus and leading to the tissue structure damage, physiological abnormality, and even organ failure until death. Up to now, there is still no specific drugs or strategies can effectively block or changeover tissue fibrosis. JNKs, a subset of mitogen-activated protein kinases (MAPK), have been reported that participates in various biological processes, such as genetic expression, DNA damage, and cell activation/proliferation/death pathways. Increasing studies indicated that abnormal regulation of JNK signal pathway has strongly associated with tissue fibrosis. Aim of Review: This review designed to sum up the molecular mechanism progresses in the role of JNK signal pathway in organ fibrosis, hoping to provide a novel therapy strategy to tackle tissue fibrosis. Key Scientific Concepts of Review: Recent evidence shows that JNK signaling pathway could modulates inflammation, immunoreaction, oxidative stress and Multiple cell biological functions in organ fibrosis. Therefore, targeting the JNK pathway may be a useful strategy in cure fibrosis. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024. Production and hosting by Elsevier B.V.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu