| Autor: |
Vandenberghe C; Health and Social Services Centre University Institute of Geriatrics of Sherbrooke Research Centre on Aging, Sherbrooke, Quebec, Canada; Camille.Vandenberghe@USherbrooke.ca., Hardy E; Clinique nutritive, Sherbrooke, Quebec, Canada; elisabelle@cliniquenutritive.com., Morin MC; Health and Social Services Centre University Institute of Geriatrics of Sherbrooke Research Centre on Aging, Sherbrooke, Quebec, Canada; Marie.Christine.Morin@USherbrooke.ca., St-Pierre V; Health and Social Services Centre University Institute of Geriatrics of Sherbrooke Research Centre on Aging, Sherbrooke, Quebec, Canada; Valerie.R.St-Pierre@USherbrooke.ca., Groulx K; Health and Social Services Centre University Institute of Geriatrics of Sherbrooke Research Centre on Aging, Sherbrooke, Quebec, Canada; Karine.Groulx@USherbrooke.ca., Fortier M; Health and Social Services Centre University Institute of Geriatrics of Sherbrooke Research Centre on Aging, Sherbrooke, Quebec, Canada; Melanie.Fortier2@USherbrooke.ca., Tessier D; Health and Social Services Centre University Institute of Geriatrics of Sherbrooke Research Centre on Aging, Sherbrooke, Quebec, Canada.; University of Sherbrooke, Médecine, Sherbrooke, Quebec, Canada; Daniel.Tessier@usherbrooke.ca., Leclerc P; Senior residence the Vü, Sherbrooke, Quebec, Canada; dg@residencelevu.com., Cunnane SC; Health and Social Services Centre University Institute of Geriatrics of Sherbrooke Research Centre on Aging, Sherbrooke, Quebec, Canada.; University of Sherbrooke, Sherbrooke, Quebec, Canada; Stephen.Cunnane@USherbrooke.ca. |
| Abstrakt: |
Poor glucose regulation associated with gradual insulin resistance is a significant risk factor in several age-related chronic diseases. An eating plan that promotes a lower carbohydrate intake may have a beneficial effect on glucose metabolism. This study aimed to evaluate how a diet reduced carbohydrate by 32% (RCHO) over a 2-month period would influence the metabolic profile of older individuals (N = 24) living in a retirement home (RH). A continuous glucose monitor was used to measure blood glucose during four periods: the standard diet before (baseline) and after (washout) the intervention, during the 4 initial days of the RCHO diet (RCHO-early), and the final days of the 2-month intervention (RCHO-end). The blood metabolic profile was also measured (glucose, ketones, insulin, triglycerides and cholesterol). RCHO intake decreased average blood glucose compared to the standard diet in hyperglycemic participants: RCHO-early 7.8 ± 1.0 vs 7.5 ± 1.1 mM (p = 0.012) and RCHO-end 7.8 ± 1.0 vs 7.0 ± 0.9 mM (p = 0.050). In the hyperglycemic participants, the percentage of time spent in hyperglycemia (> 10.0 mM) decreased by 50% during the RCHO-early (p = 0.012) and by 66% at RCHO-end (p = 0.021) compared to baseline. Glycated hemoglobin was significantly lower at RCHO-end in both hyperglycemic and normoglycemic participants compared to baseline (p < 0.008). Plasma ketones increased 3-fold in hyperglycemic participants at RCHO-end compared to baseline (p < 0.028). This study shows that an RCHO diet has metabolic health benefits in an older population and confirms its safety, tolerability, and acceptability in a RH. (NCT06022094). |
