| Autor: |
Poomrattanangoon S; Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 2G6, Canada.; Materials Science and Engineering Program, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.; Nanobiotechnology and Nanobiomaterials Research Laboratory, School of Materials Science and Innovation, Faculty of Science, Mahidol University, Bangkok 10400, Thailand., Ounkaew A; Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 2G6, Canada., Pissuwan D; Materials Science and Engineering Program, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.; Nanobiotechnology and Nanobiomaterials Research Laboratory, School of Materials Science and Innovation, Faculty of Science, Mahidol University, Bangkok 10400, Thailand., Narain R; Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 2G6, Canada. |
| Abstrakt: |
Gold nanorods (GNRs) are unique nanoparticles with easily functionalized surfaces, multiple synthesis methods, photothermal conversion, and surface plasmon resonance effects. These properties make GNRs suitable for various biological applications. However, a rapid synthesis of GNRs using less toxic chemicals is needed. The photochemical method is a viable option that can synthesize GNRs quickly while using fewer chemicals. A photochemical method is reported for the synthesis of GNRs using Irgacure-2959 as a reducing agent. This method could be used to synthesize GNRs with a rod-like shape within 30 min. Additionally, GNRs were coated with sericin (GNRs-SC) to further reduce their toxicity in human dermal fibroblast adult cells. Low-level near-infrared (NIR) light was applied to enhance the photothermal therapy of both GNRs and GNRs-SC. The results showed that GNRs and GNRs-SC under low-level NIR light have enhanced antibacterial activity against Staphylococcus aureus and Escherichia coli , as well as antibiofilm activity against S. aureus . Furthermore, GNRs-SC showed good biocompatibility with antibacterial and antibiofilm activities. These results indicate that GNRs-SC are good candidates for various biological applications. |
