Do Large Language Model Chatbots perform better than established patient information resources in answering patient questions? A comparative study on melanoma.

Autor:	Kamminga NC; Department of Dermatology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, The Netherlands., Kievits JE; Department of Dermatology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, The Netherlands.; Department of Surgery, Albert Schweitzer hospital, Dordrecht, The Netherlands., Plaisier PW; Department of Surgery, Albert Schweitzer hospital, Dordrecht, The Netherlands., Burgers JS; Dutch College of General Practitioners, PO Box 3231, Utrecht,  The Netherlands.; Care and Public Health Research Institute, Department Family Medicine, Maastricht UMC+, Maastricht, The Netherlands., van der Veldt AM; Department of Radiology & Nuclear Medicine, Erasmus MC Cancer Institute, University Medical Center Rotterdam, The Netherlands.; Department of Medical Oncology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, The Netherlands., van den Brand JAGJ; Research Suite/DataHub, Erasmus MC, Rotterdam, The Netherlands., Mulder M; Department of Medical Oncology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, The Netherlands., Wakkee M; Department of Dermatology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, The Netherlands., Lugtenberg M; Department of Dermatology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, The Netherlands.; Department Tranzo, Tilburg School of Social and Behavioral Sciences, Tilburg University, Tilburg, The Netherlands., Nijsten T; Department of Dermatology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	The British journal of dermatology [Br J Dermatol] 2024 Oct 04. Date of Electronic Publication: 2024 Oct 04.
DOI:	10.1093/bjd/ljae377
Abstrakt:	Background: Large Language Models (LLMs) have a potential role in providing adequate patient information. Objectives: To compare the quality of LLMs' responses with established Dutch patient information resources (PIRs) in answering patient questions regarding melanoma. Methods: Responses from ChatGPT versions 3.5 and 4.0, Gemini, and three leading Dutch melanoma PIRs to 50 melanoma-specific questions were examined at baseline and for LLMs again after eight months. Outcomes included (medical) accuracy, completeness, personalisation, readability, and additionally reproducibility for LLMs. Comparative analyses were performed within LLMs and PIRs using Friedman's ANOVA, and between best-performing LLMs and gold-standard PIR using Wilcoxon Signed Ranks test. Results: Within LLMs, ChatGPT-3.5 demonstrated the highest accuracy (p=0.009). Gemini performed best in completeness (p<0.001), personalisation (p=0.007), and readability (p<0.001). PIRs were consistent in accuracy and completeness, with the general practitioner's website excelling in personalisation (p=0.013) and readability (p<0.001). The best-performing LLMs outperformed the gold-standard PIR on all criteria except accuracy. Over time, response reproducibility decreased for all LLMs, showing variability across outcomes. Conclusions: Although LLMs show potential in providing highly personalised and complete responses to patient questions regarding melanoma, improving and safeguarding accuracy, reproducibility and accessibility is crucial before they can replace or complement conventional PIRs.This study compared the quality of responses from Large Language Models (LLMs) with established Dutch patient information resources (PIRs) for melanoma-related patient questions. Results showed LLMs provided highly personalised and complete answers, often surpassing PIRs. However, improving and safeguarding accuracy, reproducibility and accessibility is crucial before they can replace or complement conventional PIRs. (© The Author(s) 2024. Published by Oxford University Press on behalf of British Association of Dermatologists.)
Databáze:	MEDLINE
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