Association of circulating fatty acids with cardiovascular disease risk: Analysis of individual-level data in three large prospective cohorts and updated meta-analysis.

Autor:	Shi F; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Chowdhury R; Stempel College of Public Health and Social Work, Florida International University, Miami, FL, USA., Sofianopoulou E; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Koulman A; Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Sun L; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Steur M; Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands., Aleksandrova K; Biomarkers and Metabolism Research Group, Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology, Bremen, Germany.; Faculty of Human and Health Sciences, University of Bremen, Bremen, Germany., Dahm CC; Department of Public Health, Aarhus University, Aarhus, Denmark., Schulze MB; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany., van der Schouw YT; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Agnoli C; Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Amiano P; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP)  Madrid  Spain.; Ministry of Health of the Basque Government Sub Directorate for Public Health and Addictions of Gipuzkoa San Sebastian  Spain.; Biodonostia Health Research Institute Epidemiology of Chronic and Communicable Diseases Group San Sebastian  Spain., Boer JMA; National Institute of Public Health and the Environment, Bilthoven, The Netherlands., Bork CS; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark., Cabrera-Castro N; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP)  Madrid  Spain.; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain., Eichelmann F; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Elbaz A; Paris-Saclay University, UVSQ, Inserm, Gustave Roussy, CESP, Villejuif, France., Farràs M; Unit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet de Llobregat, Spain., Heath AK; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Kaaks R; Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Katzke V; Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Keski-Rahkonen P; Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Masala G; Clinical Epidemiology Unit, Institute for cancer research, prevention and clinical network (ISPRO) Florence, Italy., Moreno-Iribas C; Instituto de Salud Pública y Laboral de Navarra, 31003 Pamplona, Spain.; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain.; Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain., Panico S; School of Medicine, Federico II University, Naples, Italy., Papier K; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Petrova D; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain.; Escuela Andaluza de Salud Pública (EASP), 18011 Granada, Spain.; Instituto de Investigación Biosanitaria ibsGRANADA, 18012 Granada, Spain., Quirós JR; Public Health Directorate, Asturias, Spain., Ricceri F; Centre for Biostatistics, Epidemiology, and Public Health (C-BEPH), Department of Clinical and Biological Sciences, University of Turin, Italy., Severi G; Paris-Saclay University, UVSQ, Inserm, Gustave Roussy, CESP, Villejuif, France.; Department of Statistics, Computer Science, Applications 'G Parenti', University of Florence, Florence, Italy., Tjønneland A; The Danish Cancer Institute, Strandboulevarden 49, 2100 Copenhagen O, Denmark.; Department of Public Health, University of Copenghagen, Copenhagen, Denmark., Tong TYN; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Tumino R; Hyblean Association for Epidemiological Research (AIRE -ONLUS), Ragusa, Italy., Wareham N; Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Weiderpass E; International Agency for Research on Cancer (IARC/WHO), Lyon, France., Di Angelantonio E; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; BHF Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Hinxton, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Health Data Science Centre, Human Technopole, Milan, Italy., Forouhi N; Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Danesh J; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; BHF Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Hinxton, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK., Butterworth AS; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; BHF Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Hinxton, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK., Kaptoge S; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.
Jazyk:	angličtina
Zdroj:	European journal of preventive cardiology [Eur J Prev Cardiol] 2024 Oct 04. Date of Electronic Publication: 2024 Oct 04.
DOI:	10.1093/eurjpc/zwae315
Abstrakt:	Background: Associations of saturated and unsaturated fatty acids (FAs) with cardiovascular disease (CVD) remain controversial. We therefore aimed to investigate the prospective associations of objectively measured FAs with CVD, including incident coronary heart disease (CHD) and stroke, as well as CVD mortality. Methods: Circulating FA concentrations expressed as the percentage of total FAs were assayed in 172,891 participants without prior vascular disease at baseline from the European Prospective Investigation into Cancer and Nutrition-CVD (EPIC-CVD) (7,343 CHD; 6,499 stroke), UK Biobank (1,825; 1,474), and INTERVAL (285; 209) cohort studies. Hazard ratio (HR) per 1-standard deviation (SD) higher FA concentrations was estimated using Cox regression models and pooled by random-effects meta-analysis. Systematic reviews with meta-analysis published by 6 May 2023 on associations between FAs and CVDs were systematically searched and updated meta-analyses using random-effects model were conducted. Evidence from randomized controlled trials (RCTs) was also summarized. Results: Higher concentrations of total saturated FAs (SFAs) were associated with higher cardiovascular risks in the combined analysis, with differential findings noted for SFA subtypes in further analysis restricted to EPIC-CVD: positive associations for even-chain SFA [HR for CHD 1.24 (95% CI: 1.18-1.32); stroke 1.23 (1.10-1.38)] and negative associations for odd-chain [0.82 (0.76-0.87); 0.73 (0.67-0.78)] and longer-chain [0.95 (0.80-1.12); 0.84 (0.72-0.99)] SFA. In the combined analysis, total n-3 polyunsaturated FA (PUFA) [0.91 (0.85-0.97)], including docosahexaenoic acid (DHA) [0.91 (0.84-0.98)], was negatively associated with incident CHD risk. Similarly, total n-6 PUFA [0.94 (0.91-0.98)], including linoleic acid (LA) [0.89 (0.83-0.95)], was negatively associated with incident stroke risk. By contrast, more detailed analyses in EPIC-CVD revealed that several downstream n-6 PUFAs of LA were positively associated with CHD risk. Updated meta-analyses of 37 FAs including 49 non-overlapping studies, involving between 7,787 to 22,802 CHD and 6,499 to 14,221 stroke cases, showed broadly similar results as our combined empirical analysis and further suggested significant inverse associations of individual long-chain n-3 PUFAs and LA on both CHD and stroke. The findings of long-chain n-3 PUFAs were consistent with those from published RCTs on CHD despite insufficient evidence in monotherapy, while RCT evidence remained unclear for the rest of the explored FAs. Conclusions: Our study provides an overview of the most recent evidence on the associations between objectively measured FAs and CVD outcomes. Collectively, the data reveals notable differences in associations by SFA subtypes and calls for further studies, especially RCTs, to explore these links. (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)
Databáze:	MEDLINE
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