Impaired head circumference growth and behavioural problems in childhood: Longitudinal findings from the MINA-Brazil birth cohort.

Autor: Giacomini I; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil., Villamor E; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA., Lourenço BH; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil., Zhu M; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA., Seeley AL; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA., Matijasevich A; Departamento de Medicina Preventiva, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil., Cardoso MA; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil.; Global Health and Tropical Medicine, GHTM, Associate Laboratory in Translation and Innovation Towards Global Health, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa UNL, Lisbon, Portugal.
Jazyk: angličtina
Zdroj: Paediatric and perinatal epidemiology [Paediatr Perinat Epidemiol] 2024 Oct 04. Date of Electronic Publication: 2024 Oct 04.
DOI: 10.1111/ppe.13130
Abstrakt: Background: Previous evidence on the relation between early head circumference (HC) growth and behavioural outcomes in preschoolers has been inconsistent.
Objective: We aimed to investigate whether HC growth from birth to 5 years of age was related to internalising or externalising behavioural problems at 5 years of age in a sex-specific manner.
Methods: Among 303 girls and 318 boys from the MINA-Brazil birth cohort, we examined the associations between changes in HC from birth to 5 years of age and internalising and externalising behaviour problem scores at 5 years according to the Strengths and Difficulties Questionnaire for parents. HC values were transformed into sex- and age-specific z-scores (HCZ) using World Health Organisation standards, and the differences between values at 5 years of age and birth were classified into quintiles. We estimated adjusted mean differences with 95% confidence intervals in behavioural problem scores between HCZ change quintiles using multivariable linear regression by sex. To examine nonlinear associations, we included cubic spline terms.
Results: Head circumference growth from birth to 5 years of age was inversely and nonlinearly associated with internalising problems in girls. Compared with girls at the lowest quintile of HC growth, those above had an adjusted 1.27 (95% confidence interval 0.28, 2.27) points lower mean internalising problems score. This association was mostly driven by HC growth during the first 2 years. We found no association between HC growth and externalising behaviour in either sex.
Conclusions: Impaired HC growth was related to higher mean internalising problem scores at 5 years of age in girls but not in boys. HC growth was not associated with externalising problems.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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