The Effectiveness of Vitamin D Intake in Improving Symptoms and Relapses of Multiple Sclerosis: A Systematic Review.

Autor:	Gill A; Internal Medicine, Christian Medical College & Hospital, Ludhiana, IND.; Internal Medicine and Neurology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Orji C; Orthopedics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Reghefaoui M; Internal Medicine, University of Debrecen, Debrecen, HUN., Peresuodei TS; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Thota P; College of Medicine, Siddhartha Medical College, Vijayawada, IND., Saavedra Palacios MS; College of Medicine, University of Cuenca, Cuenca, ECU., Arcia Franchini AP; Psychiatry and Behavioral Sciences, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Sep 03; Vol. 16 (9), pp. e68565. Date of Electronic Publication: 2024 Sep 03 (Print Publication: 2024).
DOI:	10.7759/cureus.68565
Abstrakt:	There are disagreements over the effectiveness of vitamin D supplementation in treating multiple sclerosis (MS) patients' symptoms and reducing relapses. The goal of this systematic review is to assess the effect of vitamin D supplements on improving symptoms and relapses in MS patients. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic review was conducted by searching eight databases: Embase, PubMed, Cochrane Library, MEDLINE, CINAHL, Web of Science, Scopus, and Google Scholar. The RoB 2 tool was used to evaluate the quality of the studies that were included in the analysis. From the 1,345 studies identified, 16 randomized controlled trials were selected. All studies reported that vitamin D administration significantly increased the mean serum 25(OH)D compared with the placebo group. Also, most included studies revealed a significant improvement in magnetic resonance imaging (MRI) brain lesion markers. However, most studies showed that being treated with vitamin D instead of placebo showed no significant effect on relapse rates, fatigue, Expanded Disability Status Scale (EDSS), serum neurofilament light chain (NfL), calcium, and cytokine levels, except for quality-of-life transforming growth factor beta (TGF-β). This systematic review shows that the effect of vitamin D supplements on improving symptoms and relapses during treatment in MS patients remains inconclusive. Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Gill et al.)
Databáze:	MEDLINE
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