Sorafenib maintenance after allogeneic stem cell transplantation in patients with FLT3+ AML receiving midostaurin during induction and consolidation: a retrospective analysis.

Autor:	Sapienza G; Bone Marrow Transplantation (BMT) Unit, AOR Villa Sofia-Vincenzo Cervello, Palermo, Italy., Castronovo M; Bone Marrow Transplantation (BMT) Unit, AOR Villa Sofia-Vincenzo Cervello, Palermo, Italy., Tringali S; Bone Marrow Transplantation (BMT) Unit, AOR Villa Sofia-Vincenzo Cervello, Palermo, Italy., Bono R; Bone Marrow Transplantation (BMT) Unit, AOR Villa Sofia-Vincenzo Cervello, Palermo, Italy., Rotolo C; Bone Marrow Transplantation (BMT) Unit, AOR Villa Sofia-Vincenzo Cervello, Palermo, Italy., Mulè A; Onco-Hematology Unit, AOR Villa Sofia-Vincenzo Cervello, Palermo, Italy., Calafiore V; Onco-Hematology Unit, AOR Villa Sofia-Vincenzo Cervello, Palermo, Italy., Patti C; Onco-Hematology Unit, AOR Villa Sofia-Vincenzo Cervello, Palermo, Italy., Agueli C; Onco-Hematology and Cell Manipulation Laboratory Unit, AOR Villa Sofia-Vincenzo Cervello, Palermo, Italy., Randazzo V; Onco-Hematology and Cell Manipulation Laboratory Unit, AOR Villa Sofia-Vincenzo Cervello, Palermo, Italy., Santoro A; Onco-Hematology and Cell Manipulation Laboratory Unit, AOR Villa Sofia-Vincenzo Cervello, Palermo, Italy., Matranga D; Department of Health Promotion, Mother and Childcare, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy., Castagna L; Bone Marrow Transplantation (BMT) Unit, AOR Villa Sofia-Vincenzo Cervello, Palermo, Italy.
Jazyk:	angličtina
Zdroj:	Frontiers in oncology [Front Oncol] 2024 Sep 19; Vol. 14, pp. 1441254. Date of Electronic Publication: 2024 Sep 19 (Print Publication: 2024).
DOI:	10.3389/fonc.2024.1441254
Abstrakt:	Introduction: Acute myeloid leukemia (AML) relapse is the main cause of death after allogeneic stem cell transplant (allo-SCT). In AML FLT3+, it was shown that Sorafenib used as maintenance therapy after allo-SCT, significantly reduces the risk of relapse and death. Methods: We analyzed 29 adult patients with FLT3m AML and underwent allogeneic stem cell transplant from 2019 to 2023. All patients received midostaurin plus conventional CT during induction and consolidation. After transplantation, Sorafenib maintenance was administered in all patients independently from MRD status at transplantation. Results: Sorafenib maintenance was applied in 18 patients out 29 patients (62%). Median time to start sorafenib was 100 days (range 37-225) and median duration of treatment was 775 days (range 140-1064). For the whole population (n=29), 2-year OS, LFS, and CIR was 76%, 68% and 28%, respectively. The median time to relapse was 137 days (range 49-246). For patients treated with sorafenib (n=18), the 2-year OS, LFS, and CIR were 94%, 84% and 11%, respectively. For the whole population, the 100-day NRM was 0% and 1-year NRM was 3%. Death was caused by transplant-associated thrombotic microangiopathy in 1 patient. For patients who were administered with Sorafenib, the 1-y NRM was 5%. Death was caused by transplant associated transplant-associated thrombotic microangiopathy. Discussion: This retrospective study suggests that sorafenib maintenance seem to be effective even in patients pre-treated with midostaurin. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Sapienza, Castronovo, Tringali, Bono, Rotolo, Mulè, Calafiore, Patti, Agueli, Randazzo, Santoro, Matranga and Castagna.)
Databáze:	MEDLINE
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