Integrating the Memory Support Intervention into the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C): can improving memory for treatment in midlife and older adults improve patient outcomes? Study protocol for a randomized controlled trial.

Autor: Milner AE; Department of Psychology, University of California, Berkeley, CA, USA., Hache RE; Department of Psychology, University of California, Berkeley, CA, USA., Oliver S; Department of Psychology, University of California, Berkeley, CA, USA., Sarfan LD; Department of Psychology, University of California, Berkeley, CA, USA., Spencer JM; Department of Psychology, University of California, Berkeley, CA, USA., Cogan A; Department of Psychology, University of California, Berkeley, CA, USA., Jiang Y; Department of Psychology, University of California, Berkeley, CA, USA., Agnew ER; Department of Psychology, University of California, Berkeley, CA, USA., Zieve GG; Oakland Cognitive Behavior Therapy Center, Oakland, CA, USA., Martin JL; Geriatric Research, Education, and Clinical Center, VA Greater Los Angeles Healthcare System, Los Angeles, USA.; Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, USA., Zeidler MR; UCLA Health Pulmonology, Los Angeles, CA, USA., Dong L; Behavioral and Policy Sciences, RAND Corporation, Santa Monica, CA, USA., Carpenter JK; National Center for PTSD, Women's Health Sciences Division, VA Boston Healthcare System, Boston, MA, USA., Varghese J; Department of Psychology, University of California, Berkeley, CA, USA., Bol K; Department of Psychology, University of California, Berkeley, CA, USA., Bajwa Z; Department of Psychology, University of California, Berkeley, CA, USA., Tighe CA; Department of Psychology, Providence College, Providence, RI, USA., Harvey AG; Department of Psychology, University of California, Berkeley, CA, USA. aharvey@berkeley.edu.
Jazyk: angličtina
Zdroj: Trials [Trials] 2024 Oct 03; Vol. 25 (1), pp. 650. Date of Electronic Publication: 2024 Oct 03.
DOI: 10.1186/s13063-024-08468-0
Abstrakt: Background: Poor memory for treatment is associated with poorer treatment adherence and poorer patient outcomes. The memory support intervention (MSI) was developed to improve patient memory for treatment with the goal of improving patient outcomes. The aim of this study protocol is to conduct a confirmatory efficacy trial to test whether a new, streamlined, and potent version of the MSI improves outcomes for midlife and older adults. This streamlined MSI is comprised of constructive memory supports that will be applied to a broader range of treatment content. The platform for this study is the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C). We will focus on midlife and older adults who are low income and experiencing mobility impairments.
Methods: Participants (N = 178) will be randomly allocated to TranS-C + MSI or TranS-C alone. Both intervention arms include eight 50-min weekly sessions. Assessments will be conducted at pre-treatment, post-treatment, 6-, and 12-month follow-up (6FU and 12FU). Aim 1 will compare the effects of TranS-C + MSI versus TranS-C alone on sleep and circadian functioning, daytime functioning, well-being, and patient memory. Aim 2 will test whether patient memory for treatment mediates the relationship between treatment condition and patient outcomes. Aim 3 will evaluate if previously reported poor treatment response subgroups will moderate the relationship between treatment condition and (a) patient memory for treatment and (b) treatment outcome. Exploratory analyses will compare treatment condition on (a) patient adherence, patient-rated treatment credibility, and patient utilization of treatment contents, and (b) provider-rated acceptability, appropriateness, and feasibility.
Discussion: This study has the potential to provide evidence for (a) the efficacy of a new simplified version of the MSI for maintaining health, well-being, and functioning, (b) the wider application of the MSI for midlife and older adults and to the treatment of sleep and circadian problems, and (c) the efficacy of the MSI for sub-groups who are likely to benefit from the intervention.
Trial Registration: ClinicalTrials.gov NCT05986604. Registered on 2 August 2023.
(© 2024. The Author(s).)
Databáze: MEDLINE
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