Survey on adverse events associated with drug therapy for breast cancer patients.

Autor: Hara F; The Cancer Institute Hospital Of JFCR, 3-8-31 Ariake, Koto-ku, Tokyo, Japan. fumikatahara@gmail.com., Nagasaki R; The Cancer Institute Hospital Of JFCR, 3-8-31 Ariake, Koto-ku, Tokyo, Japan., Minami R; Daiichi Sankyo Co., Ltd, 3-5-1 Nihonbashi-honcho, Chuo-ku, Tokyo, Japan., Izutani T; Daiichi Sankyo Co., Ltd, 3-5-1 Nihonbashi-honcho, Chuo-ku, Tokyo, Japan., Yoshida T; Daiichi Sankyo Co., Ltd, 3-5-1 Nihonbashi-honcho, Chuo-ku, Tokyo, Japan., Arai A; Daiichi Sankyo Co., Ltd, 3-5-1 Nihonbashi-honcho, Chuo-ku, Tokyo, Japan., Nihei A; QLife, Inc, Toranomon33Mori-Bld. 10F, 3-8-21 Toranomon, Minato-ku, Tokyo, Japan., Sakurai N; Cancer Survivors Recruiting Project, General Incorporated Association, Daishin Building 4F-401, 2-9 Kanda Nishikicho, Chiyoda-ku, Tokyo, Japan., Ohno S; Sagara Hospital, Social Medical Corporation Hakuaikai, 3-31 Matsubara-cho, Kagoshima-shi, Kagoshima, Japan.
Jazyk: angličtina
Zdroj: BMC women's health [BMC Womens Health] 2024 Oct 03; Vol. 24 (1), pp. 545. Date of Electronic Publication: 2024 Oct 03.
DOI: 10.1186/s12905-024-03355-x
Abstrakt: Background: In the breast cancer treatment, there may be a gap between patients' information needs and physicians' perceptions. To address this issue, we conducted a comprehensive questionnaire survey aimed to assess the specific information needs of patients regarding the adverse events (AEs) associated with treatment.
Methods: A web-based questionnaire survey (UMIN000049280: Registered on October 31, 2022) was conducted in patients with a history of breast cancer treatment. Responses were obtained regarding AEs experienced, AEs for which remedies were identified, AEs patients sought to prevent, and pre-treatment information on AEs patients desired to have.
Results: Data from 435 breast cancer patients were analyzed. The most common AEs reported included hair loss (93.3%), malaise/fatigue (89.4%), nail changes (83.2%), dysgeusia (69.0%), leukopenia/white blood cell decreased (65.1%), neuropathy (62.3%), and nausea/vomiting (61.4%). Financial anxiety was reported in 35.2% of the participants. AEs for which a minority of patients found effective solutions included neuropathy (20.3%), financial anxiety (21.6%), edema (24.3%), joint pain (26.0%), and malaise/fatigue (26.7%). Patients expressed the greatest desire to avoid hair loss (34.7%), followed by nausea/vomiting (23.7%), interstitial lung disease/pneumonitis (5.5%), malaise/fatigue (5.1%), and dysgeusia (5.1%). The most commonly requested pre-treatment information regarding AEs was their duration, followed by prevention methods, management strategies, time to onset, and the impact on daily life.
Conclusions: This survey highlights the existence of significant unmet medical needs among breast cancer patients, due to the inadequate solutions available for managing AEs associated with various therapeutic agents. In addition, the survey revealed that patients have different information needs regarding different types of AEs.
(© 2024. The Author(s).)
Databáze: MEDLINE
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