Do stress hormones influence choice? A systematic review of pharmacological interventions on the HPA axis and/or SAM system.

Autor:	Sarmiento LF; BiotechMed Center, BME Lab, Multimedia Systems Department, Faculty of Electronics, Telecommunications, and Informatics, Gdansk University of Technology, Gdansk 80-233, Poland., Ríos-Flórez JA; Professor at the Faculty of Law and Forensic Sciences, Tecnológico de Antioquia University Institution, Medellín 050034, Colombia., Rincón Uribe FA; Department of postgraduation in Psychology, Federal University from Pará, Belém 66075-110, Brazil., Rodrigues Lima R; Laboratory of Functional and Structural and Biology, Federal University from Pará, Belém 66075-110, Brazil., Kalenscher T; Comparative Psychology, Institute of Experimental Psychology, Heinrich Heine University Düsseldorf, 40225, Germany., Gouveia A Jr; Laboratory of Neuroscience and Behavior, Federal University from Pará, Belém 66075-110, Brazil., Nitsch FJ; Marketing Area, INSEAD, Fontainebleau 77300, France.; Paris Brain Institute (ICM), Sorbonne University, Paris 75013, France.
Jazyk:	angličtina
Zdroj:	Social cognitive and affective neuroscience [Soc Cogn Affect Neurosci] 2024 Oct 23; Vol. 19 (1).
DOI:	10.1093/scan/nsae069
Abstrakt:	The hypothalamus-pituitary-adrenal axis (HPA axis) and the sympathetic-adrenal-medullary system (SAM system), two neuroendocrine systems associated with the stress response, have often been implicated to modulate decision-making in various domains. This systematic review summarizes the scientific evidence on the effects of pharmacological HPA axis and SAM system modulation on decision-making. We found 6375 references, of which 17 studies fulfilled our inclusion criteria. We quantified the risk of bias in our results with respect to missing outcome data, measurements, and selection of the reported results. The included studies administered hydrocortisone, fludrocortisone (HPA axis stimulants), yohimbine, reboxetine (SAM system stimulants), and/or propranolol (SAM system inhibitor). Integrating the evidence, we found that SAM system stimulation had no impact on risk aversion, loss aversion or intertemporal choice, while SAM system inhibition showed a tentative reduction in sensitivity to losses. HPA axis stimulation had no effect on loss aversion or reward anticipation but likely a time-dependent effect on decision under risk. Lastly, combined stimulation of both systems exhibited inconsistent results that could be explained by dose differences (loss aversion) and sex differences (risk aversion). Future research should address time-, dose-, and sex-dependencies of pharmacological effects on decision-making. (© The Author(s) 2024. Published by Oxford University Press.)
Databáze:	MEDLINE
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