A systematic review and quality assessment of economic evaluations of kidney replacement therapies in end-stage kidney disease.

Autor: Nyokabi P; Mahidol University Health Technology Assessment Graduate Program, Bangkok, Thailand.; Ministry of Health, Nairobi, Kenya., Youngkong S; Mahidol University Health Technology Assessment Graduate Program, Bangkok, Thailand. sitaporn.you@mahidol.edu.; Social and Administrative Pharmacy Division, Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand. sitaporn.you@mahidol.edu., Bagepally BS; Indian Council of Medical Research (ICMR), National Institute of Epidemiology, Chennai, India., Okech T; Mahidol University Health Technology Assessment Graduate Program, Bangkok, Thailand.; Ministry of Health, Nairobi, Kenya., Chaikledkaew U; Mahidol University Health Technology Assessment Graduate Program, Bangkok, Thailand. usa.chi@mahidol.ac.th.; Social and Administrative Pharmacy Division, Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand. usa.chi@mahidol.ac.th., McKay GJ; Centre for Public Health, Queen's University Belfast, Belfast, United Kingdom., Attia J; Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia., Thakkinstian A; Mahidol University Health Technology Assessment Graduate Program, Bangkok, Thailand.; Department of Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Oct 03; Vol. 14 (1), pp. 23018. Date of Electronic Publication: 2024 Oct 03.
DOI: 10.1038/s41598-024-73735-8
Abstrakt: End-stage kidney disease (ESKD) is fatal without treatment by kidney replacement therapies (KRTs). However, access to these treatment modalities can be problematic given the high costs. This systematic review (SR) aims to provide an updated economic evaluation of pairwise comparisons of KRTs and the implications for the proportion of patients with access to the KRT modalities, i.e., kidney transplantation (KT), hemodialysis (HD), and peritoneal dialysis (PD). This SR was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020. We searched studies in PubMed, Embase, Scopus, and Cost Effectiveness Analysis (CEA) registry, from inception to March 2023. Thirteen studies were included with pairwise comparisons among three KRTs, with varying proportions of patients for each modality. Seven studies were from high-income countries, including five from Europe. Summary findings are presented on a cost-effectiveness plane and incremental net benefit (INB). KT was the most cost-effective intervention across the pairwise comparisons. KT and PD were both more cost-effective alternatives to HD. HD was more costly and less effective than PD in all studies except one. Concurrent efforts to increase both KT and PD represented the best scenario to improve treatment options for ESKD patients.
(© 2024. The Author(s).)
Databáze: MEDLINE
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