Understanding the emergence of highly pathogenic avian influenza A virus H5N1 in pinnipeds: An evolutionary approach.

Autor: Paz M; Laboratorio de Virología Molecular, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Igua 4225, Montevideo 11400, Uruguay; Laboratorio de Evolución Experimental de Virus, Institut Pasteur de Montevideo, Mataojo 2020, Montevideo 11400, Uruguay; Centro de Innovación en Vigilancia Epidemiológica, Institut Pasteur Montevideo, Mataojo 2020, Montevideo 11400, Uruguay. Electronic address: mpaz@pasteur.edu.uy., Franco-Trecu V; Departamento de Ecología y Evolución, Facultad de Ciencias, Igua 4224, 11400 Montevideo, Uruguay. Electronic address: vfranco-trecu@fcien.edu.uy., Szteren D; Departamento de Ecología y Evolución, Facultad de Ciencias, Igua 4224, 11400 Montevideo, Uruguay. Electronic address: diana@fcien.edu.uy., Costábile A; Laboratorio de Virología Molecular, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Igua 4225, Montevideo 11400, Uruguay; Laboratorio de Evolución Experimental de Virus, Institut Pasteur de Montevideo, Mataojo 2020, Montevideo 11400, Uruguay; Centro de Innovación en Vigilancia Epidemiológica, Institut Pasteur Montevideo, Mataojo 2020, Montevideo 11400, Uruguay. Electronic address: acostabile@fcien.edu.uy., Portela C; Laboratorio de Evolución Experimental de Virus, Institut Pasteur de Montevideo, Mataojo 2020, Montevideo 11400, Uruguay; Centro de Innovación en Vigilancia Epidemiológica, Institut Pasteur Montevideo, Mataojo 2020, Montevideo 11400, Uruguay. Electronic address: cportela@pasteur.edu.uy., Bruno A; Instituto Nacional de Salud Pública e Investigación 'Leopoldo Izquieta-Pérez', Guayaquil, Ecuador; Universidad Agraria del Ecuador, Ecuador., Moratorio G; Laboratorio de Virología Molecular, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Igua 4225, Montevideo 11400, Uruguay; Laboratorio de Evolución Experimental de Virus, Institut Pasteur de Montevideo, Mataojo 2020, Montevideo 11400, Uruguay; Centro de Innovación en Vigilancia Epidemiológica, Institut Pasteur Montevideo, Mataojo 2020, Montevideo 11400, Uruguay., Moreno P; Laboratorio de Virología Molecular, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Igua 4225, Montevideo 11400, Uruguay; Laboratorio de Evolución Experimental de Virus, Institut Pasteur de Montevideo, Mataojo 2020, Montevideo 11400, Uruguay; Centro de Innovación en Vigilancia Epidemiológica, Institut Pasteur Montevideo, Mataojo 2020, Montevideo 11400, Uruguay. Electronic address: pmoreno@fcien.edu.uy., Cristina J; Laboratorio de Virología Molecular, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Igua 4225, Montevideo 11400, Uruguay. Electronic address: cristina@cin.edu.uy.
Jazyk: angličtina
Zdroj: Virus research [Virus Res] 2024 Dec; Vol. 350, pp. 199472. Date of Electronic Publication: 2024 Oct 05.
DOI: 10.1016/j.virusres.2024.199472
Abstrakt: Highly pathogenic influenza A virus (HPIAV) H5N1 within the genetic clade 2.3.4.4b has emerged in wild birds in different regions of the world, leading to the death of >70 million birds. When these strains spread to pinniped species a remarkable mortality has also been observed. A detailed genetic characterization of HPIAV isolated from pinnipeds is essential to understand the potential spread of these viruses to other mammalian species, including humans. To gain insight into these matters a detailed phylogenetic analysis of HPIAV H5N1 2.3.4.4b strains isolated from pinniped species was performed. The results of these studies revealed multiple transmission events from birds to pinnipeds in all world regions. Different evolutionary histories of different genes of HPIAV H5N1 2.3.4.4b strains gave rise to the viruses infecting pinnipeds in different regions of the world. European strains isolated from pinnipeds represent a completely different genetic lineage from strains isolated from South American ones. All strains isolated from pinnipeds bear characteristics of a highly pathogenic form for of avian influenza in poultry. Amino acid substitutions, previously shown to confer an adaptive advantage for infecting mammals, were observed in different genes in all pinniped species studied.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The funding institutions has no role in the decision of publishing of this manuscript.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: