Childhood Developmental Milestones and Risk of Adult Cerebrovascular Disease: The Northern Finland Birth Cohort 1966.

Autor:	Kivelä M; Research Unit of Population Health, University of Oulu, Oulu, Finland.; Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland., Rissanen I; Research Unit of Population Health, University of Oulu, Oulu, Finland.; Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Kajantie E; Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland.; PEDEGO Research Unit, Oulu University Hospital and University of Oulu, Oulu, Finland.; Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Ojaniemi M; Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland.; Department of Children and Adolescents, Oulu University Hospital, Wellbeing Services County of North Ostrobothnia Oulu, Oulu, Finland., Rusanen H; Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland.; Department of Neurology, Oulu University Hospital, Oulu, Finland., Miettunen J; Research Unit of Population Health, University of Oulu, Oulu, Finland.; Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland., Paananen M; Research Unit of Population Health, University of Oulu, Oulu, Finland.; Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland.
Jazyk:	angličtina
Zdroj:	Cerebrovascular diseases (Basel, Switzerland) [Cerebrovasc Dis] 2024 Oct 03, pp. 1-11. Date of Electronic Publication: 2024 Oct 03.
DOI:	10.1159/000541702
Abstrakt:	Introduction: To the best of our knowledge, no previous studies have examined the relationship between childhood developmental milestones and risk of adulthood cerebrovascular disease (CeVD). We studied whether the risk of adult CeVD is associated with delayed attainment of motor and language milestones. Methods: Within the Northern Finland Birth Cohort 1966, a total of 11,688 persons were followed from birth to either death, moving abroad or 54 years of age. CeVD diagnoses, i.e., ischemic and hemorrhagic strokes and transient ischemic attacks, were extracted from national registers with diagnostic coding based on recommendations of the World Health Organization. Cox proportional hazard models stratified by sex were used to estimate associations of motor development and language milestones between ages 0 and 4 years and adult CeVD women-to-men relative hazard ratios (RHRs) were estimated for each developmental milestone. Analyses were adjusted for family socioeconomic status and birth weight for gestational age. Results: Altogether 498 (4.3%) CeVDs were recorded during follow-up. Among both sexes, later turning from back to tummy was associated with ischemic CeVD in adulthood with an adjusted hazard ratio (aHR) of 1.25 and 95% confidence interval (CI) 1.06-1.46 for men and an aHR: 1.20 (CI: 1.02-1.42) for women per 1 month delay in achievement. Delayed overall motor development, modeled by motor milestone principal component score, was related to increased risk of ischemic CeVD (aHR: 1.50; CI: 1.03-2.19) among men. Later achievement of making sounds was associated with any CeVD (aHR: 2.74; CI: 1.39-5.40) and especially ischemic CeVD (aHR: 3.41; CI: 1.65-7.06) among men with women-to-men RHR's of 0.17 (95% CI: 0.04-0.81) for any CeVD and RHR 0.18 (95% CI: 0.04-0.89) for ischemic stroke indicating risk to be lower in women compared to men. Conclusions: These findings suggest that later achievement of childhood milestones could be a predictor for development of CeVD risk. The results point toward a common neurodevelopmental background and could in part explain lifetime CeVD risk accumulation. (© 2024 The Author(s). Published by S. Karger AG, Basel.)
Databáze:	MEDLINE
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