Overcoming Biopotency Barriers: Advanced Oral Delivery Strategies for Enhancing the Efficacy of Bioactive Food Ingredients.

Autor: Liu L; College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, 712100, China., McClements DJ; Department of Food Science, University of Massachusetts Amherst, Amherst, MA, 01003, USA., Liu X; College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, 712100, China., Liu F; College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Jazyk: angličtina
Zdroj: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Nov; Vol. 11 (44), pp. e2401172. Date of Electronic Publication: 2024 Oct 03.
DOI: 10.1002/advs.202401172
Abstrakt: Bioactive food ingredients contribute to the promotion and maintenance of human health and wellbeing. However, these functional ingredients often exhibit low biopotency after food processing or gastrointestinal transit. Well-designed oral delivery systems can increase the ability of bioactive food ingredients to resist harsh environments inside and outside the human body, as well as allow for controlled or triggered release of bioactives to specific sites in the gastrointestinal tract or other tissues and organs. This review presents the characteristics of common bioactive food ingredients and then highlights the barriers to their biopotency. It also discusses various oral delivery strategies and carrier types that can be used to overcome these biopotency barriers, with a focus on recent advances in the field. Additionally, the advantages and disadvantages of different delivery strategies are highlighted. Finally, the current challenges facing the development of food-grade oral delivery systems are addressed, and areas where future research can lead to new advances and industrial applications of these systems are proposed.
(© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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