Regulation and signaling of the LIM domain kinases.

Autor: Casanova-Sepúlveda G; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA., Boggon TJ; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA.; Department of Pharmacology, Yale University, New Haven, Connecticut, USA.; Yale Cancer Center, Yale University, New Haven, Connecticut, USA.
Jazyk: angličtina
Zdroj: BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2024 Oct 03, pp. e2400184. Date of Electronic Publication: 2024 Oct 03.
DOI: 10.1002/bies.202400184
Abstrakt: The LIM domain kinases (LIMKs) are important actin cytoskeleton regulators. These proteins, LIMK1 and LIMK2, are nodes downstream of Rho GTPases and are the key enzymes that phosphorylate cofilin/actin depolymerization factors to regulate filament severing. They therefore perform an essential role in cascades that control actin depolymerization. Signaling of the LIMKs is carefully regulated by numerous inter- and intra-molecular mechanisms. In this review, we discuss recent findings that improve the understanding of LIM domain kinase regulation mechanisms. We also provide an up-to-date review of the role of the LIM domain kinases, their architectural features, how activity is impacted by other proteins, and the implications of these findings for human health and disease.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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