Outcomes of kidney transplantation in recipients with SARS-cov-2 infection: a 282-case single-center experience in Japan.

Autor: Sekido E; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan., Unagami K; Department of Nephrology, Tokyo Women's Medical University, Tokyo, Japan. unagami.kohei@twmu.ac.jp.; Department of Organ Transplant Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan. unagami.kohei@twmu.ac.jp., Omoto K; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.; Tokiwakai Yochomachi Clinic, Tokyo, Japan., Arimura K; Department of Pulmonology, Tokyo Women's Medical University, Tokyo, Japan., Moriyama I; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan., Banno T; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan., Saitoh A; Department of Organ Transplant Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan., Oki R; Department of Organ Transplant Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan., Okada D; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan., Yagisawa T; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan., Kanzawa T; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan., Kitajima K; Department of Organ Transplant Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan., Hirai T; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan., Shimizu T; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.; Department of Organ Transplant Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan., Yamanaga S; Department of Surgery, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan., Egawa H; Department of Surgery, Tokyo Women's Medical University, Tokyo, Japan., Inui M; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.; Department of Urology, Tokyo Women's Medical University Yachiyo Medical Center, Chiba, Japan., Hoshino J; Department of Nephrology, Tokyo Women's Medical University, Tokyo, Japan., Ishida H; Department of Organ Transplant Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan., Takagi T; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
Jazyk: angličtina
Zdroj: Clinical and experimental nephrology [Clin Exp Nephrol] 2024 Oct 03. Date of Electronic Publication: 2024 Oct 03.
DOI: 10.1007/s10157-024-02560-0
Abstrakt: Background: The coronavirus disease 2019, caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has become a global epidemic. There are concerns regarding the severity of SARS-CoV-2 infections in kidney transplant (KTx) recipients. However, there is limited data on how the epidemic has affected the treatment and prognosis of these patients. Therefore, we aimed to report the changes in the treatment and outcomes of KTx recipients infected with SARS-CoV-2 during each wave at our institution.
Methods: A total of 282 KTx recipients who were infected with SARS-CoV-2 during the study period were followed up at Tokyo Women's Medical University between March 2020 and August 2022. We investigated the outcomes and treatments of infected KTx recipients.
Results: Nineteen (6.7%) patients showed severe outcomes, including eight SARS-CoV-2 infection-related deaths. Risk factors associated with severe outcomes included underlying conditions, such as diabetes mellitus, heart disease, and liver disease (odds ratios, 2.09, 2.88, and 5.52, respectively). Treatment strategies changed throughout the epidemic in response to changes in the SARS-CoV-2 variants. Antiviral drugs were gradually administered as soon as they were approved for use.
Conclusions: Treatment strategies for KTx recipients were gradually established over the course of the epidemic. Although the proportion of infected KTx recipients decreased compared to that of the general population throughout the epidemic, many patients still followed a severe course.
(© 2024. The Author(s), under exclusive licence to Japanese Society of Nephrology.)
Databáze: MEDLINE
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