Clinical application of photoacoustic imaging for cervical precursor lesion detection.

Autor: Okawa KS; Department of Obstetrics and Gynecology, Seirei Hamamatsu General Hospital, 2-1212 Sumiyoshi, Chuo-ku, Hamamatsu, Shizuoka, Japan. kiguna0309@gmail.com., Okawa S; Department of Medical Engineering, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, Japan.; Biomedical Instrumentation Laboratory, Research and Development in Photonics Technology, Institute of Photonics Medicine, Hamamatsu University School of Medicine, 1- 20-1 Handayama, Chuo-ku, Hamamatsu, Shizuoka, Japan., Sasa H; Department of Obstetrics and Gynecology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, Japan., Ishihara M; Department of Medical Engineering, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, Japan.
Jazyk: angličtina
Zdroj: Journal of medical ultrasonics (2001) [J Med Ultrason (2001)] 2024 Oct 03. Date of Electronic Publication: 2024 Oct 03.
DOI: 10.1007/s10396-024-01501-4
Abstrakt: Purpose: Early diagnosis of a precursor lesion in the uterine cervix is an essential factor in uterine cervical cancer prevention. Although colposcopy is an established procedure for detecting high-risk patients, its accuracy and reproducibility are relatively low. Some supportive or alternative techniques to improve the early diagnosis of a precursor lesion have been studied, and correct diagnosis with high reliability using a minimally invasive, cost-effective technique has been pursued. This study aimed to examine the possibility of using photoacoustic (PA) imaging as a supportive technique to improve the accuracy of early diagnosis of cervical precursor lesions.
Methods: A PA imaging system for microvessels was used to detect angiogenesis in severe lesions. A total of 21 patients who underwent surgical treatment and 114 outpatients who visited our colposcopy clinic were examined. A retrospective evaluation of PA images was performed as follows: (i) pathological assessment of the specific PA findings and (ii) retrospective evaluation of the severe lesion detection rate through PA.
Results: PA image evaluation and pathological findings showed dense angiogenesis in a severe precursor lesion appearing as a "hot spot" in the PA image. A comparison with colposcopy findings was performed for accuracy evaluation, and the detection rate of severe lesions using PA was relatively high (positive predictive value, 84.5%; negative predictive value, 82.1%).
Conclusion: Our results indicate the possibility of using PA imaging for early diagnosis of severe cervical precursor lesions. With its ability to yield quantitative information, PA imaging can improve ultrasound diagnosis.
(© 2024. The Author(s), under exclusive licence to The Japan Society of Ultrasonics in Medicine.)
Databáze: MEDLINE
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