Female sexual dysfunctions in multiple sclerosis patients with lower urinary tract symptoms: an Italian case-control study.

Autor:	Balsamo R; Department of Surgical Sciences, AORN dei Colli/Monaldi Hospital, Naples 80131, Italy., Crocetto F; Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples 80131, Italy., Barone B; Department of Surgical Sciences, AORN Sant'anna e Sebastiano, Caserta 81100, Italy., Fusco F; Urology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples 80131, Italy., Arcaniolo D; Urology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples 80131, Italy., Costantini E; Andrology and Urogynecological Clinic, Santa Maria Hospital Terni, University of Perugia, Perugia 05100, Italy., Illiano E; Andrology and Urogynecological Clinic, Santa Maria Hospital Terni, University of Perugia, Perugia 05100, Italy., Amicuzi U; Department of Surgical Sciences, AORN Sant'anna e Sebastiano, Caserta 81100, Italy., Torella M; Urology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples 80131, Italy., Ranavolo R; Department of Surgical Sciences, AORN dei Colli/Monaldi Hospital, Naples 80131, Italy., Quattrone C; Urology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples 80131, Italy., De Sio M; Urology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples 80131, Italy., Tammaro S; Urology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples 80131, Italy.
Jazyk:	angličtina
Zdroj:	Sexual medicine [Sex Med] 2024 Oct 01; Vol. 12 (5), pp. qfae054. Date of Electronic Publication: 2024 Oct 01 (Print Publication: 2024).
DOI:	10.1093/sexmed/qfae054
Abstrakt:	Background: Multiple sclerosis (MS) is a recurrent, autoimmune, and inflammatory demyelinating chronic disease that typically manifests in young adulthood and exerts adverse effects on sexual functions. Aim: The study evaluated the prevalence of sexual dysfunctions (SDs) and the relationship with neurological disability, depression, and lower urinary tract symptoms (LUTS) in a cohort of MS female patients, comparing these results with those of healthy women. Methods: From January 2023 to January 2024, consecutive premenopausal female patients with MS, were recruited and the examination included urinalysis, ultrasonography and a urodynamic test according to the International Continence Society standard. Outcomes: Descriptive statistics were reported as mean and standard deviation for continuous variables (analyzed by independent samples Mann-Whitney U test and independent samples Kruskal-Wallis test) while categorical variables were reported as frequency and percentage (analyzed by chi-square test with Fisher's exact test). Results: Female Sexual Function Index (FSFI) total score and all FSFI subscales scores were significantly lower in patients with MS vs healthy control subjects ( P < .001); FSFI total scores and all FSFI subscale scores were statistically significantly lower in patients with MS with an International Prostate Symptom Score ≥20 ( P < .001) and considering a cutoff for Beck Depression Inventory-II score ≥17, depression was present in 61% (n = 47 of 77) of patients with MS and completely absent in the control group. Clinical Translation: The knowledge that SDs are a common problem in MS and in other chronic illnesses can alleviate the feeling of stigma and talking openly of sexual problems can be helpful for the patients and so the doctor-patient relationship can be reinforced. Strengths and Limitations: The sample was drawn from a single center, and larger multicenter studies that include both genders are needed to obtain strong results. Conclusion: Our findings confirm the idea of a polygenic and multifactorial etiology of female SDs in MS. Therefore, women with MS should be evaluated in terms of SDs during follow-ups. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© The Author(s) 2024. Published by Oxford University Press on behalf of The International Society for Sexual Medicine.)
Databáze:	MEDLINE
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