Comparing postoperative pain relief: ketorolac and Nasocalcin spray versus lidocaine and Nasocalcin spray in abdominal surgery patients.

Autor:	Saadat Fakhr M; Faculty of Medicine, Tehran Medical Sciences Branch, Islamic Azad University., Qasemi M; Faculty of Medicine, Tehran Medical Sciences Branch, Islamic Azad University., Rezvanfar K; Faculty of Medicine, Tehran Medical Sciences Branch, Islamic Azad University., Hosseini RS; Istanbul Medipol University, Faculty of Medicine, Medical Student, Istanbul, Turkey., Amini Z; Faculty of Medicine, Tehran Medical Sciences Branch, Islamic Azad University., Amiri K; Faculty of Medicine, Tehran Medical Sciences Branch, Islamic Azad University., Zhaleh M; Faculty of Medicine, Tehran Medical Sciences Branch, Islamic Azad University., Tarkashvand T; Faculty of Medicine, Tehran Medical Sciences Branch, Islamic Azad University., Narimani Zamanabadi M; Department of Anesthesiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Jazyk:	angličtina
Zdroj:	Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2024 Aug 30; Vol. 86 (10), pp. 5823-5829. Date of Electronic Publication: 2024 Aug 30 (Print Publication: 2024).
DOI:	10.1097/MS9.0000000000002285
Abstrakt:	Objectives: Postoperative pain management is critical for patient recovery after abdominal surgery. This study compared intravenous lidocaine and ketorolac for reducing postoperative pain and opioid use, along with Nasocalcin nasal spray. Methods: In this randomized controlled trial, 58 abdominal surgery patients were allocated to receive either intravenous lidocaine plus Nasocalcin spray ( n =29) or intravenous ketorolac plus Nasocalcin spray ( n =29) before surgery. Pain intensity (visual analog scale) and postoperative opioid consumption were assessed at 1, 6, 12, and 24 h after surgery. Results: Patients receiving ketorolac plus Nasocalcin spray reported significantly lower pain scores at all time points compared to lidocaine plus Nasocalcin ( P <0.001). Average 24-h pain scores were 4.5 with ketorolac versus 5.1 with lidocaine. Mean opioid consumption was also lower in the ketorolac group (31.9 mg) versus the lidocaine group (43.9 mg, P <0.001). Conclusion: Preoperative ketorolac plus Nasocalcin nasal spray resulted in superior pain relief and less opioid use compared to lidocaine plus Nasocalcin after abdominal surgery. Ketorolac may be a more effective analgesic option, while Nasocalcin spray is a safe adjunct. These findings can inform clinical practice for optimizing postoperative analgesia. Competing Interests: The authors deny any conflict of interest in any terms or by any means during the study. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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