Comparison of the effect of use of preoperative mexiletine tablets and control on reducing postoperative pain in patients undergoing abdominal surgery.

Autor:	Saadat Fakhr M; Faculty of Medicine, Tehran Medical Sciences Branch, Islamic Azad University., Jadididavodabadi A; Faculty of Medicine, Tehran Medical Sciences Branch, Islamic Azad University., Rezvanfar K; Faculty of Medicine, Tehran Medical Sciences Branch, Islamic Azad University., Amini Z; Faculty of Medicine, Tehran Medical Sciences Branch, Islamic Azad University., Amiri K; Faculty of Medicine, Tehran Medical Sciences Branch, Islamic Azad University., Narimani Zamanabadi M; Department of Anesthesiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Jazyk:	angličtina
Zdroj:	Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2024 Aug 22; Vol. 86 (10), pp. 5817-5822. Date of Electronic Publication: 2024 Aug 22 (Print Publication: 2024).
DOI:	10.1097/MS9.0000000000002251
Abstrakt:	Objective: Postoperative pain is a major concern for patients and healthcare providers following abdominal surgery. This study aimed to compare the effectiveness of mexiletine in reducing postoperative pain in patients undergoing abdominal surgery. Methods: In this double-blind randomized controlled trial, 34 patients were divided into two groups. One group received 600 mg of mexiletine tablets, while the other group received vitamin C tablets (control) two hours before surgery. Postoperative pain levels were assessed at 6, 12, and 24 h by using the Visual Analog Scale (VAS). Additionally, the amount of narcotics received within the first 24 h after surgery was recorded. Results: The results showed that the average postoperative pain score in patients who received mexiletine was significantly lower than in those who received vitamin C tablets ( P <0.001). Furthermore, the average amount of narcotics received after surgery was significantly lower in the mexiletine group compared to the control group ( P =0.03). Pain scores at 6, 12, and 24 h after surgery were also significantly lower in the mexiletine group ( P <0.001). Conclusion: Mexiletine was effective in reducing postoperative pain and the need for narcotics in patients undergoing abdominal surgery. This study highlights the potential of mexiletine as a valuable preoperative intervention for postoperative pain management. Competing Interests: The authors deny any conflict of interest in any terms or by any means during the study. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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