Exploring the potential of selenium nanoparticles and fabricated selenium nanoparticles @vitamin C nanocomposite in mitigating nicotine-induced testicular toxicity in rats.

Autor:	Hindawy RF; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Benha University, Al Nadi Al Ryadi, Qism Benha, Al-Qalyubia Governorate, Benha 13518, Egypt., Refaat RMM; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Benha University, Al Nadi Al Ryadi, Qism Benha, Al-Qalyubia Governorate, Benha 13518, Egypt., Fouda AE; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Benha University, Al Nadi Al Ryadi, Qism Benha, Al-Qalyubia Governorate, Benha 13518, Egypt., El-Shishtawy MA; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Benha University, Al Nadi Al Ryadi, Qism Benha, Al-Qalyubia Governorate, Benha 13518, Egypt., Kumar A; Department of Forensic Medicine and Toxicology, All India Institute of Medical Sciences (AIIMS), AIIMS Campus, Ansari Nagar East, New Delhi, India., El-Shafai NM; Nanotechnology Center, Chemistry Department, Faculty of Science, Kafrelsheikh University, Qism Kafr El-Shaikh, Kafr Al Sheikh First, Kafr El-Sheikh Governorate, Kafrelsheikh 33516, Egypt., Faruk EM; Anatomy Department, College of Medicine, Umm Al-Qura University, College of Medicine, Umm Al-Qura, University, Al Abidiyah, Makkah, Saudi Arabia.; Department of Histology and Cytology, Faculty of Medicine, Benha University, Al Nadi Al Ryadi, Qism Benha, Al-Qalyubia Governorate, Benha, Egypt., Nafea OE; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Zagazig University, Zagazig Rd inside Zagazig University, Shaibet an Nakareyah, Al-Sharqia Governorate, Zagazig 44519, Egypt.
Jazyk:	angličtina
Zdroj:	Toxicology research [Toxicol Res (Camb)] 2024 Sep 30; Vol. 13 (5), pp. tfae154. Date of Electronic Publication: 2024 Sep 30 (Print Publication: 2024).
DOI:	10.1093/toxres/tfae154
Abstrakt:	Background: The tobacco epidemic signifies a major public health threat. Nicotine (NIC), a major active constituent in tobacco, impedes male fertility and semen quality. This work is implemented to explore the potential of selenium nanoparticles (SeNPs) and the newly fabricated SeNPs @vitamin C (SeNPs@VITC) nanocomposite in mitigating testicular toxicity induced by NIC. Materials and Methods: The six groups of 48 adult Wistar rats were designed as follows: the control group injected intraperitoneally with normal saline, the SeNPs group treated orally with 2 mg/kg of SeNPs, the SeNPs@VITC nanocomposite group treated orally with 2 mg/kg of SeNPs@VITC nanocomposite, the NIC group injected intraperitoneally with 1.25 mL/kg of NIC, the NIC+ SeNPs group received SeNPs plus NIC, and the NIC+ SeNPs@VITC nanocomposite group received SeNPs@VITC nanocomposite plus NIC. Treatments were administered over a 28-day period. Results: NIC treatment significantly caused poor sperm quality, decreased serum testosterone, increased follicle-stimulating hormone (FSH), luteinizing hormone (LH) concentrations, reduced hemoglobin levels, leukocytosis, disrupted testicular oxidant/antioxidant balance, and disorganized testicular structure. The construction of the novel SeNPs@VITC nanocomposite, compared to NIC plus SeNPs alone, demonstrated a more potent ameliorative effect on NIC-induced reproductive toxicity in adult rats. The SeNPs@VITC nanocomposite significantly increased sperm count, reduced the percentage of sperm head abnormalities, lowered both serum FSH and LH concentrations, and improved the hemoglobin response. Conclusions: Both SeNPs and SeNPs@VITC nanocomposite alleviated the testicular toxicity induced by NIC, but the SeNPs@VITC nanocomposite exhibited superior efficacy. The SeNPs@VITC nanocomposite could be employed to advance enhanced therapeutic strategies for addressing male infertility. (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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