Depression and Plasma pTau 181 Levels Are Associated with Frailty Status in Hispanic Community-Dwelling Older Women.

Autor:	Rangel GA; Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT-AIP), Panama City, Panama.; Panama's Secretaría Nacional de Ciencia Tecnología e Innovación (SENACYT), Panama., Tratner AE; Panama's Secretaría Nacional de Ciencia Tecnología e Innovación (SENACYT), Panama.; Sistema Nacional de Investigación (SNI), Secretaría Nacional de Ciencia, Tecnología e Innovación (SENACYT), Panamá., Oviedo DC; Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT-AIP), Panama City, Panama.; Panama's Secretaría Nacional de Ciencia Tecnología e Innovación (SENACYT), Panama.; Universidad Católica Santa María La Antigua, Panama City, Panamá., Villarreal AE; Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT-AIP), Panama City, Panama.; Panama's Secretaría Nacional de Ciencia Tecnología e Innovación (SENACYT), Panama., Carreira MB; Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT-AIP), Panama City, Panama.; Panama's Secretaría Nacional de Ciencia Tecnología e Innovación (SENACYT), Panama., Rodriguez-Araña S; Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT-AIP), Panama City, Panama., Flores Millender E; Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT-AIP), Panama City, Panama.; Sistema Nacional de Investigación (SNI), Secretaría Nacional de Ciencia, Tecnología e Innovación (SENACYT), Panamá.; Florida State University, Tallahassee, USA., Xavier Hall C; Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT-AIP), Panama City, Panama.; Florida State University, Tallahassee, USA., Wong FY; Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT-AIP), Panama City, Panama.; Sistema Nacional de Investigación (SNI), Secretaría Nacional de Ciencia, Tecnología e Innovación (SENACYT), Panamá.; Florida State University, Tallahassee, USA., O'Bryant S; University of North Texas Health Science Center, Fort Worth, USA., Britton GB; Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT-AIP), Panama City, Panama.; Panama's Secretaría Nacional de Ciencia Tecnología e Innovación (SENACYT), Panama.; Universidad Católica Santa María La Antigua, Panama City, Panamá.
Jazyk:	angličtina
Zdroj:	Gerontology & geriatric medicine [Gerontol Geriatr Med] 2024 Sep 27; Vol. 10, pp. 23337214241283546. Date of Electronic Publication: 2024 Sep 27 (Print Publication: 2024).
DOI:	10.1177/23337214241283546
Abstrakt:	The population of Hispanic older adults is growing along with the burden of chronic diseases. This cross-sectional study aims to assess the factors associated with frailty among community-dwelling Hispanic women aged ≥60 years ( n  = 357) enrolled in the Panama Aging Research Initiative-Health Disparities study of cognitive-functional health of older persons in Panama. Cognitive function was assessed with a neuropsychological test battery. Depression was measured with the Geriatric Depression Scale. Frailty was defined using the Fried criteria and participants were classified as non-frail, pre-frail or frail. A subsample ( n  = 281) provided fasting blood samples for quantification of protein biomarkers. Associations were examined using hierarchical multiple linear regressions. 59.4% and 9.0% of participants ( M  = 69.2 years, SD  = 6.3) were pre-frail and frail, respectively. Having more depression (β = .28, p  < .001) was significantly associated with frailty, even after covariate adjustment. Cognitive function was not associated with frailty. Higher pTau181 levels were associated with increased frailty (β = .13, p  = .039), whereas higher α2M levels were associated with decreased frailty (β = -.16, p  = .004). These findings advance the search for health indicators and biomarkers of frailty and warrant further studies to decrease the burden of frailty among older Hispanic women. Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. (© The Author(s) 2024.)
Databáze:	MEDLINE
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