Strategic electrochemical oxidation of vinblastin sulfate (an anticancer drug) via PVP-functionalized strontium oxide nanoparticles.

Autor: Lanjar SU; National Centre of Excellence in Analytical Chemistry, University of Sindh Jamshoro 76080 Pakistan amber.solangi@usindh.edu.pk., Solangi AR; National Centre of Excellence in Analytical Chemistry, University of Sindh Jamshoro 76080 Pakistan amber.solangi@usindh.edu.pk., Batool N; M. A. Kazi Institute of Chemistry, University of Sindh Jamshoro-76080 Sindh Pakistan., Khand NH; National Centre of Excellence in Analytical Chemistry, University of Sindh Jamshoro 76080 Pakistan amber.solangi@usindh.edu.pk., Kamboh M; National Centre of Excellence in Analytical Chemistry, University of Sindh Jamshoro 76080 Pakistan amber.solangi@usindh.edu.pk., Malah A; M. A. Kazi Institute of Chemistry, University of Sindh Jamshoro-76080 Sindh Pakistan., Buledi JA; National Centre of Excellence in Analytical Chemistry, University of Sindh Jamshoro 76080 Pakistan amber.solangi@usindh.edu.pk., Khan MM; National Centre of Excellence in Analytical Chemistry, University of Sindh Jamshoro 76080 Pakistan amber.solangi@usindh.edu.pk.
Jazyk: angličtina
Zdroj: RSC advances [RSC Adv] 2024 Oct 02; Vol. 14 (43), pp. 31387-31397. Date of Electronic Publication: 2024 Oct 02 (Print Publication: 2024).
DOI: 10.1039/d4ra05493h
Abstrakt: Cancer is a primary cause of death worldwide, and considerably impacts mortality rates in low- and middle-income countries. The rise in chemotherapeutic patients and toxicity of cytotoxic agents highlight the need for reliable analytical methods to detect these compounds. The current study presents a simple and straightforward method for producing polyvinylpyrrolidone functionalized strontium oxide nanoparticles (PVP-SrO NPs). The synthesized PVP-SrO NPs were applied as a sensitive sensor to detect vinblastin sulfate (VNB) (an anticancer drug). The synthesized PVP-SrO NPs were characterized using different characterization techniques. Fourier transform infrared spectroscopy (FTIR) confirms the functionality of synthesized PVP-SrO NPs. The sharp intense peaks of X-ray diffraction spectroscopy (XRD) confirm the crystalline nature of NPs, scanning electron microscopy (SEM) confirm the nanobeads like morphology, and energy dispersive spectroscopy (EDS) reveals the presence of Sr and O at 68.3% and 23% respectively. The electrochemical impedance spectroscopy and cyclic voltammetry studies revealed that the PVP-SrO/GCE is more conductive than bare GCE with an R ct value of 960.4 Ω compared to 2440 Ω. The sensor exhibited a wide linear dynamic range for VNB (0.05 to 60 μM) with low LOD 0.005 μM, and LOD 0.017 μM. The proposed sensor was successfully used for monitoring VNB in human blood serum samples with a satisfactory percent recovery from 96% to 103%. The fabricated sensor exhibits better performance than the reported sensors in terms of processing, simplicity, cost-effectiveness, energy consumption, and enhanced efficacy in a very short time.
Competing Interests: There are no conflicts of interest.
(This journal is © The Royal Society of Chemistry.)
Databáze: MEDLINE
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