Impact of gluten intake on clinical outcomes in patients with chronic inflammatory diseases initiating biologics: Secondary analysis of the prospective multicentre BELIEVE cohort study.

Autor: Gregersen L; Molecular Diagnostics and Clinical Research Unit, University Hospital of Southern Denmark, Aabenraa, Denmark.; The Faculty of Health Sciences, Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Jessen PD; Molecular Diagnostics and Clinical Research Unit, University Hospital of Southern Denmark, Aabenraa, Denmark.; The Faculty of Health Sciences, Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Lund HW; Molecular Diagnostics and Clinical Research Unit, University Hospital of Southern Denmark, Aabenraa, Denmark.; The Faculty of Health Sciences, Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Overgaard SH; Molecular Diagnostics and Clinical Research Unit, University Hospital of Southern Denmark, Aabenraa, Denmark.; The Faculty of Health Sciences, Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Hikmat Z; Molecular Diagnostics and Clinical Research Unit, University Hospital of Southern Denmark, Aabenraa, Denmark.; The Faculty of Health Sciences, Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Ellingsen T; Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark., Kjeldsen J; Research Unit of Gastroenterology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark., Pedersen AK; Department of Clinical Research, University Hospital of Southern Denmark, Aabenraa, Denmark.; Open Patient Data Exploration Network (OPEN), Odense, Denmark., Petersen SR; Department of Clinical Research, University Hospital of Southern Denmark, Aabenraa, Denmark., Jawhara M; Section of Upper Benign and Hernia Surgery (G3), Department of Surgery, Odense University Hospital, Svendborg, Denmark., Nexøe AB; The Faculty of Health Sciences, Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Bygum A; Research Unit of Human Genetics, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark., Hvas CL; Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark., Dahlerup JF; Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.; The Abdominal Center, Medical Section, Bispebjerg University Hospital, Copenhagen, Denmark., Bergenheim FO; The Abdominal Center, Medical Section, Bispebjerg University Hospital, Copenhagen, Denmark., Glerup H; University Research Clinic for Innovative Patient Pathways, Silkeborg Regional Hospital, Silkeborg, Denmark., Henriksen RH; University Research Clinic for Innovative Patient Pathways, Silkeborg Regional Hospital, Silkeborg, Denmark., Guldmann T; University Research Clinic for Innovative Patient Pathways, Silkeborg Regional Hospital, Silkeborg, Denmark., Hvid L; Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark., Brodersen J; The Faculty of Health Sciences, Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.; Department of Internal Medicine-Gastroenterology, Esbjerg & Grindsted Hospital, University Hospital of Southern Denmark, Esbjerg, Denmark., Munk HL; Department of Rheumatology, Odense University Hospital, Odense, Denmark.; Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark., Pedersen N; Department of Gastroenterology, Slagelse Regional Hospital, Slagelse, Denmark., Saboori S; Department of Gastroenterology, Slagelse Regional Hospital, Slagelse, Denmark., Nielsen OH; Department of Gastroenterology, Herlev Hospital, Herlev, Denmark., Heitmann BL; Research Unit for Dietary Studies, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Haldorsson TI; Molecular Diagnostics and Clinical Research Unit, University Hospital of Southern Denmark, Aabenraa, Denmark.; Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland., Christensen R; Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark.; Section for Biostatistics and Evidence-Based Research, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Andersen V; Open Patient Data Exploration Network (OPEN), Odense, Denmark.; Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Jazyk: angličtina
Zdroj: Scandinavian journal of immunology [Scand J Immunol] 2024 Oct 02, pp. e13409. Date of Electronic Publication: 2024 Oct 02.
DOI: 10.1111/sji.13409
Abstrakt: Chronic inflammatory diseases (CIDs) pose a growing healthcare challenge, with a substantial proportion of patients showing inadequate response to biological treatment. There is renewed interest in dietary changes to optimize treatment regimens, with a growing body of evidence suggesting beneficial effects with adherence to a gluten-free diet. This study compared the likelihood of achieving clinical response to biological treatment after 14-16 weeks in patients with CID with high versus low-to-medium gluten intake. Secondary outcomes of interest included changes in disease activity, health-related quality of life and C-reactive protein. The study was a multicentre prospective cohort of 193 participants with a CID diagnosis (i.e. Crohn's Disease, Ulcerative Colitis, Rheumatoid Arthritis, Axial Spondyloarthritis, Psoriatic Arthritis or Psoriasis) who initiated biological treatment between 2017 and 2020. Participants were stratified based on their habitual gluten intake: the upper 33.3% (high gluten intake) and the remaining 66.6% (low-to-medium gluten intake). The proportion of patients achieving clinical response to biological treatment after 14-16 weeks was compared using logistic regression models. The median gluten intake differed significantly between groups (12.5 g/day vs. 5.9 g/day, standardized mean difference = 1.399). In total, 108 (56%) achieved clinical response to treatment, with no difference between 35 (55%) in the high gluten group and 73 (57%) in the medium-to-low gluten group (OR = 0.96 [0.51-1.79], p = 0.897). No differences were found with secondary outcomes. In conclusion, this study found no association between gluten intake and response to biological treatment in patients with CID.
(© 2024 The Author(s). Scandinavian Journal of Immunology published by John Wiley & Sons Ltd on behalf of The Scandinavian Foundation for Immunology.)
Databáze: MEDLINE
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