The association between serum S100β levels and prognosis in acute stroke patients after intravenous thrombolysis: a multicenter prospective cohort study.

Autor: Qu Y; Stroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, China., Jin H; Stroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, China., Abuduxukuer R; Stroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, China., Qi S; Stroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, China., Si XK; Stroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, China., Zhang P; Stroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, China., Zhang KJ; Stroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, China., Wang SJ; Stroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, China., Zheng XY; Department of Neurology, the First Hospital of Jilin University, Changchun, China., Zhang Y; Department of Neurology, Songyuan Central Hospital, Songyuan, China., Gao JH; Department of Neurology, Jilin Neuropsychiatric Hospital, Siping, China., Zhang XK; Stroke Center, Department of Neurology, Siping Central People's Hospital, Siping, China., Liu XD; Department of Neurosurgery, Tonghua City Vascular Disease Hospital and Dongchang District People's Hospital, Tonghua, China., Li CY; Department of Neurology, Songyuan Jilin Oilfield Hospital, Songyuan, China., Li GC; Stroke Center, Department of Neurology, Dehuishi People's Hospital, Changchun, China., Wang J; Department of Neurology, Affiliated Hospital of Jilin Medical College, Jilin, China., Jin H; Department of Neurology, Songyuan Hospital of Integrated Traditional Chinese and Western Medicine, Songyuan, China., He Y; Stroke Center, Department of Neurology, Qianguoerros Mongolian Autonomous County Hospital, Songyuan, China., Jiang L; Department of Neurology, Affiliated Hospital of Jilin Medical College, Jilin, China., Liu L; Department of Neurology, Jilin City Hospital of Chemical Industry, Jilin, China., Jiang Y; Department of Neurology, Changchun People's Hospital, Changchun, China.; Department of Neurology, Changchun Second Hospital, Changchun, China., Teng RH; Department of Neurology, Dongliao First People's Hospital, Liaoyuan, China., Jia Y; Department of Neurology, Jilin People's Hospital, Jilin, China., Zhang BJ; Department of Neurology, Jilin City Hospital of Chemical Industry, Jilin, China., Chen Z; Department of Neurology, Jilin City Hospital of Chemical Industry, Jilin, China., Qi Y; Department of Neurology, Jilin Province People's Hospital, Changchun, China., Liu X; Stroke Center, Department of Neurology, Jilin Central General Hospital, Jilin, China., Li S; Department of Neurology, Jilin Province People's Hospital, Changchun, China., Sun X; Stroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, China., Nguyen TN; Boston Medical Center Neurology, Radiology, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, Boston, USA., Yang Y; Stroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, China. yang_yi@jlu.edu.cn., Guo ZN; Stroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, China. zhen1ni2@jlu.edu.cn.; Neuroscience Research Center, Department of Neurology, the First Hospital of Jilin University, Changchun, China. zhen1ni2@jlu.edu.cn.
Jazyk: angličtina
Zdroj: BMC medicine [BMC Med] 2024 Oct 03; Vol. 22 (1), pp. 304. Date of Electronic Publication: 2024 Oct 03.
DOI: 10.1186/s12916-024-03517-6
Abstrakt: Background: S100β is a biomarker of astroglial damage, the level of which is significantly increased following brain injury. However, the characteristics of S100β and its association with prognosis in patients with acute ischemic stroke following intravenous thrombolysis (IVT) remain unclear.
Methods: Patients in this multicenter prospective cohort study were prospectively and consecutively recruited from 16 centers. Serum S100β levels were measured 24 h after IVT. National Institutes of Health Stroke Scale (NIHSS) and hemorrhagic transformation (HT) were measured simultaneously. NIHSS at 7 days after stroke, final infarct volume, and modified Rankin Scale (mRS) scores at 90 days were also collected. An mRS score ≥ 2 at 90 days was defined as an unfavorable outcome.
Results: A total of 1072 patients were included in the analysis. The highest S100β levels (> 0.20 ng/mL) correlated independently with HT and higher NIHSS at 24 h, higher NIHSS at 7 days, larger final infarct volume, and unfavorable outcome at 3 months. The patients were divided into two groups based on dominant and non-dominant stroke hemispheres. The highest S100β level was similarly associated with the infarct volume in patients with stroke in either hemisphere (dominant: β 36.853, 95% confidence interval (CI) 22.659-51.048, P < 0.001; non-dominant: β 23.645, 95% CI 10.774-36.516, P = 0.007). However, serum S100β levels at 24 h were more strongly associated with NIHSS scores at 24 h and 3-month unfavorable outcome in patients with dominant hemisphere stroke (NIHSS: β 3.470, 95% CI 2.392-4.548, P < 0.001; 3-month outcome: odds ratio (OR) 5.436, 95% CI 2.936-10.064, P < 0.001) than in those with non-dominant hemisphere stroke (NIHSS: β 0.326, 95% CI  - 0.735-1.387, P = 0.547; 3-month outcome: OR 0.882, 95% CI 0.538-1.445, P = 0.619). The association of S100β levels and HT was not significant in either stroke lateralization group.
Conclusions: Serum S100β levels 24 h after IVT were independently associated with HT, infarct volume, and prognosis in patients with IVT, which suggests the application value of serum S100β in judging the degree of disease and predicting prognosis.
(© 2024. The Author(s).)
Databáze: MEDLINE
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