Classifying compounds as prebiotics - scientific perspectives and recommendations.

Autor: Hutkins R; University of Nebraska, Lincoln, NE, USA., Walter J; University College Cork, Cork, Ireland., Gibson GR; Food and Nutritional Sciences, University of Reading, Reading, UK., Bedu-Ferrari C; Teagasc Food Research Centre, Cork, Ireland., Scott K; Rowett Institute, University of Aberdeen, Aberdeen, UK., Tancredi DJ; Department of Pediatrics, University of California at Davis, Sacramento, CA, USA., Wijeyesekera A; Food and Nutritional Sciences, University of Reading, Reading, UK., Sanders ME; International Scientific Association for Probiotics and Prebiotics, Centennial, CO, USA. Maryellen@isappscience.org.
Jazyk: angličtina
Zdroj: Nature reviews. Gastroenterology & hepatology [Nat Rev Gastroenterol Hepatol] 2025 Jan; Vol. 22 (1), pp. 54-70. Date of Electronic Publication: 2024 Oct 02.
DOI: 10.1038/s41575-024-00981-6
Abstrakt: Microbiomes provide key contributions to health and potentially important therapeutic targets. Conceived nearly 30 years ago, the prebiotic concept posits that targeted modulation of host microbial communities through the provision of selectively utilized growth substrates provides an effective approach to improving health. Although the basic tenets of this concept remain the same, it is timely to address certain challenges pertaining to prebiotics, including establishing that prebiotic-induced microbiota modulation causes the health outcome, determining which members within a complex microbial community directly utilize specific substrates in vivo and when those microbial effects sufficiently satisfy selectivity requirements, and clarification of the scientific principles on which the term 'prebiotic' is predicated to inspire proper use. In this Expert Recommendation, we provide a framework for the classification of compounds as prebiotics. We discuss ecological principles by which substrates modulate microbiomes and methodologies useful for characterizing such changes. We then propose statistical approaches that can be used to establish causal links between selective effects on the microbiome and health effects on the host, which can help address existing challenges. We use this information to provide the minimum criteria needed to classify compounds as prebiotics. Furthermore, communications to consumers and regulatory approaches to prebiotics worldwide are discussed.
Competing Interests: Competing interests: R.H. is a founder and co-owner of Synbiotic Health and has received grants from Mead Johnson Nutrition. J.W. is a founder and co-owner of Synbiotic Health and declares support from AgriFibre, Ingredion, MGP ingredients and ConAgra as relevant to this manuscript. G.R.G. has run various industry-funded research projects on prebiotics, none of which influenced the content of this paper. He is a non-paid adviser to the UK All Party Parliamentary Group on Microbiome. He is a member of a scientific advisory board for Deerland Probiotics & Enzymes. K.S. is a volunteer board member of the International Scientific Association for Probiotics and Prebiotics (ISAPP). She has no conflicts relevant to this manuscript. D.J.T. declares support from Deerland Probiotics & Enzymes (statistical consultant and SAB member), International Flavors and Fragrances (statistical consultant), and Synbiotic Health (statistical consultant). He is a volunteer board member of ISAPP. A.W. is a volunteer board member of ISAPP. She declares no conflicts relevant to this manuscript. M.E.S. serves as consulting scientific adviser and formerly as executive science officer for the ISAPP; she has consulted with Bayer, Pepsico, and the Bill and Melinda Gates Foundation; served on scientific advisory boards for Institute for Advancement of Food and Nutrition Sciences, United States Pharmacopeia, Danone NA, Sanofi and Cargill; and has been compensated for giving talks for Xpeer, Sanofi, European Federation of Association of Dietitians and Associated British Foods. C.B.-F. declares no competing interests.
(© 2024. Springer Nature Limited.)
Databáze: MEDLINE
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