Neural circuit mechanisms underlying context-specific halting in Drosophila.

Autor: Sapkal N; Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA.; International Max Planck Research School for Synapses and Circuits, Jupiter, FL, USA.; Florida Atlantic University, Boca Raton, FL, USA., Mancini N; Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA., Kumar DS; Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA.; International Max Planck Research School for Synapses and Circuits, Jupiter, FL, USA.; Florida Atlantic University, Boca Raton, FL, USA., Spiller N; Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA., Murakami K; Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA., Vitelli G; Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA., Bargeron B; Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA.; Florida Atlantic University, Boca Raton, FL, USA., Maier K; Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA.; Florida Atlantic University, Boca Raton, FL, USA., Eichler K; Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK., Jefferis GSXE; Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.; Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK., Shiu PK; Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA., Sterne GR; Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA.; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA., Bidaye SS; Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA. Salil.Bidaye@mpfi.org.
Jazyk: angličtina
Zdroj: Nature [Nature] 2024 Oct; Vol. 634 (8032), pp. 191-200. Date of Electronic Publication: 2024 Oct 02.
DOI: 10.1038/s41586-024-07854-7
Abstrakt: Walking is a complex motor programme involving coordinated and distributed activity across the brain and the spinal cord. Halting appropriately at the correct time is a critical component of walking control. Despite progress in identifying neurons driving halting 1-6 , the underlying neural circuit mechanisms responsible for overruling the competing walking state remain unclear. Here, using connectome-informed models 7-9 and functional studies, we explain two fundamental mechanisms by which Drosophila implement context-appropriate halting. The first mechanism ('walk-OFF') relies on GABAergic neurons that inhibit specific descending walking commands in the brain, whereas the second mechanism ('brake') relies on excitatory cholinergic neurons in the nerve cord that lead to an active arrest of stepping movements. We show that two neurons that deploy the walk-OFF mechanism inhibit distinct populations of walking-promotion neurons, leading to differential halting of forward walking or turning. The brake neurons, by constrast, override all walking commands by simultaneously inhibiting descending walking-promotion neurons and increasing the resistance at the leg joints. We characterized two behavioural contexts in which the distinct halting mechanisms were used by the animal in a mutually exclusive manner: the walk-OFF mechanism was engaged for halting during feeding and the brake mechanism was engaged for halting and stability during grooming.
(© 2024. The Author(s).)
Databáze: MEDLINE
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