Changes in pancreatic steatosis by computed tomography 24 months after sleeve gastrectomy in youth with severe obesity.
Autor: | Becetti I; Division of Pediatric Endocrinology, Mass General Hospital for Children and Harvard Medical School, Boston, Massachusetts; Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Lopez Lopez AP; Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Galbiati F; Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Pedreira CC; Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Lauze M; Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Carreno KO; Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Huber FA; Department of Radiology, Musculoskeletal Imaging and Intervention, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Bitoun O; Department of Radiology, Musculoskeletal Imaging and Intervention, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Lee H; Biostatistics Center, Massachusetts General Hospital, Boston, Massachusetts., Carmine B; Department of Surgery, Boston University Medical Center, Boston, Massachusetts., Singhal V; Division of Pediatric Endocrinology, Mass General Hospital for Children and Harvard Medical School, Boston, Massachusetts; Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Misra M; Division of Pediatric Endocrinology, Mass General Hospital for Children and Harvard Medical School, Boston, Massachusetts; Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Bredella MA; Department of Radiology, Musculoskeletal Imaging and Intervention, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Department of Radiology, NYU Langone Health, New York, New York. Electronic address: miriam.bredella@nyulangone.org. |
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Jazyk: | angličtina |
Zdroj: | Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery [Surg Obes Relat Dis] 2024 Sep 10. Date of Electronic Publication: 2024 Sep 10. |
DOI: | 10.1016/j.soard.2024.08.034 |
Abstrakt: | Background: Pancreatic steatosis has been associated with obesity and the metabolic syndrome. Studies in adults have demonstrated improvement in pancreatic steatosis following sleeve gastrectomy (SG) with concomitant improvement in glucose homeostasis. Objectives: To examine changes in pancreatic steatosis in youth with severe obesity 24 months following SG. Setting: Academic hospital system. Methods: Forty-seven youth (13-24 years) with severe obesity (37 females) were followed for 24 months; 23 had SG and 24 were nonsurgical (NS) controls. Attenuations of the pancreas and spleen were measured using computed tomography (CT) at baseline, 12- and 24-month follow-up. Subjects underwent magnetic resonance imaging (MRI) for subcutaneous and visceral adipose tissue (SAT, VAT), dual energy x-ray absorptiometry (DXA) for body composition, blood sampling for glycated hemoglobin (A1C), and fasting and postprandial insulin and glucose. Linear mixed effects (LMEs) models were used to compare within- and between-group changes over 24 months. Results: At baseline, SG had higher body mass index (BMI) versus NS (P = .033). Over 24 months, significant reductions were noted in weight, BMI, VAT, SAT, fat mass (FM), and lean mass (LM) in the SG versus NS groups (P ≤ .0001). There was a significant 24-month decrease in pancreatic steatosis in the SG group (P = .006). In the whole group, 24-month reductions in pancreatic steatosis correlated with BMI and FM decreases. No associations were found between pancreatic steatosis and glucose homeostasis parameters. Conclusions: Pancreatic steatosis measured by CT improved after SG in youth. Further studies are needed to understand the relationship between pancreatic steatosis and glucose homeostasis. (Copyright © 2024 American Society for Metabolic and Bariatric Surgery. Published by Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
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