Glial Control of Cortical Neuronal Circuit Maturation and Plasticity.
| Autor: | Faust TE; Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605 travis.faust@umassmed.edu wen.xin@ucsf.edu., Devlin BA; Department of Psychology and Neuroscience, Duke University, Durham, North Carolina 27708., Farhy-Tselnicker I; Department of Biology, Texas A&M University, College Station, Texas 77843., Ferro A; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724., Postolache M; Brain Immunology & Glia Center, Washington University School of Medicine, St. Louis, Missouri 63110.; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri 63110., Xin W; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California 94158 travis.faust@umassmed.edu wen.xin@ucsf.edu. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2024 Oct 02; Vol. 44 (40). Date of Electronic Publication: 2024 Oct 02. |
| DOI: | 10.1523/JNEUROSCI.1208-24.2024 |
| Abstrakt: | The brain is a highly adaptable organ that is molded by experience throughout life. Although the field of neuroscience has historically focused on intrinsic neuronal mechanisms of plasticity, there is growing evidence that multiple glial populations regulate the timing and extent of neuronal plasticity, particularly over the course of development. This review highlights recent discoveries on the role of glial cells in the establishment of cortical circuits and the regulation of experience-dependent neuronal plasticity during critical periods of neurodevelopment. These studies provide strong evidence that neuronal circuit maturation and plasticity are non-cell autonomous processes that require both glial-neuronal and glial-glial cross talk to proceed. We conclude by discussing open questions that will continue to guide research in this nascent field. Competing Interests: The authors declare no competing financial interests. (Copyright © 2024 the authors.) |
| Databáze: | MEDLINE |
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