Clinical Applications and Future Translation of Somatosensory Neuroprostheses.

Autor:	Graczyk E; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 emily.graczyk@case.edu.; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106., Hutchison B; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106., Valle G; Department of Electrical Engineering, Chalmers University of Technology, Goteborg 41296, Sweden.; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois 60637., Bjanes D; Division of Biology and Biological Engineering and Tianqiao & Chrissy Chen Brain-Machine Interface Center, California Institute of Technology, Pasadena, California 91125., Gates D; Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109.; School of Kinesiology, University of Michigan, Ann Arbor, Michigan 48109., Raspopovic S; Laboratory for Neuroengineering, Department of Health Sciences and Technology, Institute for Robotics and Intelligent Systems, ETH Zurich, Zurich 8092, Switzerland.; Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna 1090, Austria., Gaunt R; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, Pennsylvania 15219.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.
Jazyk:	angličtina
Zdroj:	The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2024 Oct 02; Vol. 44 (40). Date of Electronic Publication: 2024 Oct 02.
DOI:	10.1523/JNEUROSCI.1237-24.2024
Abstrakt:	Somatosensory neuroprostheses restore, replace, or enhance tactile and proprioceptive feedback for people with sensory impairments due to neurological disorders or injury. Somatosensory neuroprostheses typically couple sensor inputs from a wearable device, prosthesis, robotic device, or virtual reality system with electrical stimulation applied to the somatosensory nervous system via noninvasive or implanted interfaces. While prior research has mainly focused on technology development and proof-of-concept studies, recent acceleration of clinical studies in this area demonstrates the translational potential of somatosensory neuroprosthetic systems. In this review, we provide an overview of neurostimulation approaches currently undergoing human testing and summarize recent clinical findings on the perceptual, functional, and psychological impact of somatosensory neuroprostheses. We also cover current work toward the development of advanced stimulation paradigms to produce more natural and informative sensory feedback. Finally, we provide our perspective on the remaining challenges that need to be addressed prior to translation of somatosensory neuroprostheses. (Copyright © 2024 the authors.)
Databáze:	MEDLINE
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