HumanIslets.com: Improving accessibility, integration, and usability of human research islet data.

Autor:	Ewald JD; Institute of Parasitology, McGill University, Montreal, QC, Canada; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lu Y; Institute of Parasitology, McGill University, Montreal, QC, Canada., Ellis CE; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada., Worton J; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Surgery, University of Alberta, Edmonton, AB, Canada., Kolic J; Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada., Sasaki S; Diabetes Research Group, BC Children's Hospital Research Institute, Vancouver, BC, Canada; Department of Surgery, School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada., Zhang D; Diabetes Research Group, BC Children's Hospital Research Institute, Vancouver, BC, Canada; Department of Surgery, School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada., Dos Santos T; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada., Spigelman AF; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada., Bautista A; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada., Dai XQ; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada., Lyon JG; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada., Smith NP; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada., Wong JM; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Surgery, University of Alberta, Edmonton, AB, Canada., Rajesh V; Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA, USA., Sun H; Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA, USA., Sharp SA; Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA, USA., Rogalski JC; Department of Biochemistry & Molecular Biology, Michael Smith Laboratories, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada., Moravcova R; Department of Biochemistry & Molecular Biology, Michael Smith Laboratories, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada., Cen HH; Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada., Manning Fox JE; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada., Atlas E; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada., Bruin JE; Department of Biology & Institute of Biochemistry, Carleton University, Ottawa, ON, Canada., Mulvihill EE; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Heart Institute, Ottawa, ON, Canada., Verchere CB; Department of Surgery, BC Children's Hospital Research Institute and University of British Columbia, Vancouver, BC, Canada; Department of Pathology and Laboratory Medicine, BC Children's Hospital Research Institute and University of British Columbia, Vancouver, BC, Canada; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada., Foster LJ; Department of Biochemistry & Molecular Biology, Michael Smith Laboratories, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada., Gloyn AL; Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA, USA; Stanford Diabetes Research Center, Stanford School of Medicine, Stanford, CA, USA; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Johnson JD; Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada., Pepper AR; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Surgery, University of Alberta, Edmonton, AB, Canada., Lynn FC; Diabetes Research Group, BC Children's Hospital Research Institute, Vancouver, BC, Canada; Department of Surgery, School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada., Xia J; Institute of Parasitology, McGill University, Montreal, QC, Canada. Electronic address: jeff.xia@mcgill.ca., MacDonald PE; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada; Division of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, MI, USA. Electronic address: pmacdonald@ualberta.ca.
Jazyk:	angličtina
Zdroj:	Cell metabolism [Cell Metab] 2024 Sep 24. Date of Electronic Publication: 2024 Sep 24.
DOI:	10.1016/j.cmet.2024.09.001
Abstrakt:	HumanIslets.com supports diabetes research by offering easy access to islet phenotyping data, analysis tools, and data download. It includes molecular omics, islet and cellular function assays, tissue processing metadata, and phenotypes from 547 donors. As it expands, the resource aims to improve human islet data quality, usability, and accessibility. Competing Interests: Declaration of interests A.L.G.’s spouse is an employee of Genentech and holds stock options in Roche. A.R.P. serves on the Scientific Advisory Committee for Encellin Inc. J.X. is founder of XiaLab Analytics, which provides omics data science training and support. (Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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