Pyroptosis in lung cancer: The emerging role of non-coding RNAs.

Autor: Thangavelu L; Centre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, India., Goyal A; Institute of Pharmaceutical Research, GLA University, Mathura, UP, India., Afzal M; Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah 21442, Saudi Arabia., Moglad E; Department of Pharmaceutics, College of Pharmacy, Prince Sattam bin Abdulaziz University, Alkharj 11942, Saudi Arabia., Rawat S; Graphic Era (Deemed to be University), Clement Town, 248002, Dehradun, India., Kazmi I; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Alzarea SI; Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Al-Jouf 72341, Saudi Arabia., Almalki WH; Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia., Rani R; University Centre for Research and Development, Chandigarh University, Mohali, Punjab 140413, India., Madhubabu P; KKR and KSR Institute of Technology and Sciences, Guntur, India. Electronic address: madhubabu.pusuluri@outlook.com., Rajput P; Uttaranchal Institute of Pharmaceutical Sciences, Division of Research and Innovation, Uttaranchal University, India., Bansal P; Department of Applied Sciences, Chandigarh Engineering College, Chandigarh Group of Colleges, Jhanjeri, Mohali 140307, Punjab, India.
Jazyk: angličtina
Zdroj: Pathology, research and practice [Pathol Res Pract] 2024 Nov; Vol. 263, pp. 155619. Date of Electronic Publication: 2024 Sep 28.
DOI: 10.1016/j.prp.2024.155619
Abstrakt: Lung cancer remains an intractable malignancy worldwide, prompting novel therapeutic modalities. Pyroptosis, a lethal form of programmed cell death featured by inflammation, has been involved in cancer progression and treatment response. Simultaneously, non-coding RNA has been shown to have important roles in coordinating pattern formation and oncogenic pathways, including long non-coding RNA (lncRNAs), microRNA (miRNAs), circular RNA (circRNAs), and small interfering RNA (siRNAs). Recent studies have revealed that ncRNAs can promote or inhibit pyroptosis by interacting with key molecular players such as NLRP3, GSDMD, and various transcription factors. This dual role of ncRNAs offers a unique therapeutic potential to manipulate pyroptosis pathways, providing opportunities for innovative cancer treatments. In this review, we integrate current research findings to propose novel strategies for leveraging ncRNA-mediated pyroptosis as a therapeutic intervention in lung cancer. We explore the potential of ncRNAs as biomarkers for predicting patient response to treatment and as targets for overcoming resistance to conventional therapies.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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