Etiological Profile of First Episode Seizures in Paediatric Patients at a Tertiary Care Centre: A Descriptive Cross-sectional Study.

Autor:	Shah M; Nobel Medical College Teaching Hospital, Biratnagar, Morang, Nepal., Poudel S; Nobel Medical College Teaching Hospital, Biratnagar, Morang, Nepal., Parajuli B; Nobel Medical College Teaching Hospital, Biratnagar, Morang, Nepal., Kc N; Nobel Medical College Teaching Hospital, Biratnagar, Morang, Nepal., Kc R; Nepal Medical College Teaching Hospital, Jorpati, Kathmandu, Nepal.
Jazyk:	angličtina
Zdroj:	JNMA; journal of the Nepal Medical Association [JNMA J Nepal Med Assoc] 2024 Mar 31; Vol. 62 (272), pp. 232-237. Date of Electronic Publication: 2024 Mar 31.
DOI:	10.31729/jnma.8535
Abstrakt:	Introduction: Seizures are the most common neurological emergency and one of the most common reasons for paediatrics hospital admissions. This study aimed to identify the etiology, clinical profile, and immediate outcome of children with the first episode of seizure in Eastern Nepal. Methods: This was a prospective descriptive study carried out in the Tertiary Care Centre from September 2022 to August 2023. Ethical clearance was taken from the Institutional Review Committee (Ref no:654/2022). Convenience sampling was done to include 170 children presenting with the first episode of seizure at age 6 months to 15 years. Variables collected were demographics, clinical presentations, family history, trauma history, laboratory tests, neuroimaging, EEG, final diagnosis, and immediate outcome. Results: A total of 170 patients were admitted with the first episode of seizure with 123 (72.36%) males and 47 (27.64%) females. The mean age of the patients was 5.13±2.95 years with 104 (61.18%) patients under 5 years of age. The most common seizure was generalized tonic-clonic type in 132 (77.64%) patients. The most common associated symptom was fever in 150 (88.23%) children. Neuroimaging was abnormal in 52 (30.59%) patients, with neurocysticercosis seen in 27 (15.88%). The most common etiology was febrile seizure in 92 (54.17%) patients, neurocysticercosis in 27 (15.88%), and meningitis in 12 (7.05%). Conclusions: Febrile seizures, neurocysticercosis, infection, and trauma were the major causes of seizures in children. When simple febrile seizures were unlikely, lumbar puncture, neuroimaging, and laboratory tests were useful tools for diagnosing etiologies of seizures.
Databáze:	MEDLINE
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